Transcript Adhatoda vasica

Anti-tussives
Vasaka
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DEPARTMENT OF TECHNICAL EDUCATION
ANDHRA PRADESH
Name
: R.D.L.P.Christian
Designation
: Lecturer in pharmacy
Branch
: Pharmacy
Institute
: GPW, Srikakulam(088)
Year
: I year
Subject
: Pharmacognosy
Subject Code
: PH-103
Topic
: Anti-tussives
Sub-Topic
: Vasaka
Duration
: 50 min.
Teaching Aids
: PPT, Photographs
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Recap
In the last class we learnt about
The Anti-hypertensive drug RAUWOLFIA
Rauwolfia contains alkaloids
the clinically most important alkaloid is Reserpine
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OBJECTIVES
On completion of this lesson, you would be able to
learn about
• The monograph of the Antistussive drug – VASAKA
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Known to Unknown
1.
Have you come across cough during cold seasons?
2.
Do you know about the drug Vasaka?
3.
Can you tell one cough syrup which contain Vasaka?
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Antitussives - Definition
• Agents used in the symptomatic control of Cough
• Depress the cough centre present in the medulla
• Also termed as Anodyne, cough suppressants and
Centrally acting Anti-tussives
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VASAKA
Syn: Arusha (Hindi) Addasaramu (Telugu)
• Biological Source :
Consists of fresh or
dried leaves of
Adhatoda vasica
• Family : Acanthaceae
• Geographical Source :
India, Burma,
Myanmar, Sri Lanka
Fig.38.1 Vasaka twig
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Collection And Cultivation
• Green shrub grows in loamy soil
• Reaches a height of 3 to 8 ft.
• Easily propagated by stem cutting and seed germination
• Obtained in all seasons of the year
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Morphological Characters
LEAF
• Size
: Length 12-20cm width 2.5-6 cm
• Shape
: Ovate - lanceolate
• Margin
: Entire or slightly crenate
• Venation : Pinnate
• Apex
: Acuminate
• Base
: Tapering
Fig.38.2 Vasaka twig
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Morphological Characters
LEAF
• Surface : Glabrous, slightly pubescent
• Petiole : 2-8cm long, grooved
• Colour : Light green
• Odour : characteristic
• Taste
Fig.38.3 Vasaka twig
: Bitter
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Chemical Constituents
• Vasaka contains Quinazoline alkaloids
• Main alkaloids are Vasicine, Vasicinone,
6-hydroxy Vasicine
• Leaves contain Volatile oil, Betain & Vasakin
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Uses
• Used as an Expectorant & Bronchodilator
• Also used as Sedative, Antispasmodic
and Anthelmentic
• Vasicine shows Oxytocic and Abortificient action
• Leaf extract cures Diarrhoea, Dysentery
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Summary
In this class we learnt about
Vasaka is an antitussive drug
Vasaka contains Quinazoline alkaloids
Vasicine, Vasicinone etc.,
Expectorant and Bronchodilator activity
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Quiz
1.
Antitussive agents are active against
a) Chest pain
b) Ulcer
c) Cough
d) Hypertension
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Quiz
2. The active constituents of Vasaka are
a) Quinazoline alkaloids
b) Indole alkaloids
c) Tropane alkaloids
d) None of the above
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Frequently Asked Questions
1.
Define antitussive. Give examples of the antitussive
drugs with the Botanical sources
2.
Mention the Botanical Source and Morphology of
Vasaka
3.
Write the Chemical constituents and uses of Vasaka
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THANK YOU
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