Transcript 18. MP and MPM that contain quinolinie and isoquinoline alka

Medicinal plant and Medicinal
plant materials that contain
quinolisidine and isoquinoline
alkaloids
MP containing quinolisidine
alkaloids
Herba Thermopsidis
Semina Thermopsidis
Thermopsis lanceolata- False lupine,
bush pea
Fabaceae
 Constituents. Herb contains up to
2.5% of alkaloids, chiefly thermopsine,
its isomer anagirine;
homothermopsine, cytysine,
methylcytysine, pachicarpine, etc.
 Seeds must contain not less than 2.5%
of cytysine.
 Uses. This drug has expectorant
properties and dry extract, tablets
against cough, dry mixture against
cough and infusion are produced from
this plant. In low dosses medicines
from thermopsis lanceolata excite
respiratory center, in high dosses can
cause vomiting and paralyze the
centres of brain and medulla
oblongata.
Herba Thermopsidis
alterniflorae
Thermopsis alternifloraFabaceae
Constituents. The main
constituent is cytysine.
 Uses. Cytyton excites
respiratory centre and
used to treat shock
conditions, intoxication
and asphyxia. Tablets
tabex are used to help
quit smoking.

Herba Sophorae pachycarpae
Sophora pachycarpaFabaceae
Constituents. Herb
and seeds contain
quinolisidine alkaloids
(2-3%), the main is
pakhycarpine (not
less than 0.5%).
 Uses. Pakhycarpine
hydroiodine is used to
stimulate delivery.

Cormi Securinegae
Securinega suffruticosa
Euphorbiaceae

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Constituents. The main
alkaloid is securenin (up to
0.3% in leaves). Except
securenin 7 other alkaloids
are found in this plant:
suphruticodine, alosecurinin,
securinol A, B, C,
dihydrosuphruticonin.
Uses. Secureninum nitrate is
used as tonic medicine to
treat palsy, neurasthenia,
sexual disorders.
MP and MPM containing
isoquinoline alkaloids
Capitata papaveris, Opium
Papaver somniferum- Opium
poppy
Papaveraceae
Constituents. Poppy capsules contain,
when ripe, 0.18-0.28% of morphine.
Poppy seeds contain only very small
quantities of narcotine, papaverine and
thebaine in addition to morphine and
codeine.
 Uses. Omnopon and morphine are strong
painkillers, which are used to reduce pain.

Codeine, codterpine, tablets against cough
are used for cough soothing. Papaverine
has spasmolitic action on blood vessels
and thus can be used to treat
hypertension, angina and migraine.
Papaverine is part of paphyllin
(papaverine + plathyphylline), papasol
(papaverine + dibazole), khelliverine
(papaverine + khellin), khellatrine
(papaverine + khelline + atropine),
bepasal, niquoverine, palufin, theoverine,
etc.
Herba Glaucii flavi
Glaucium flavum- Yellow
horn poppy
Papaveraceae

Constituents. Plant contains up to 4% of
alkaloids, the most valuable is glaucin and it
content is almost near 50% of all alkaloids,
sometimes it reaches 2% of the mass of all
aerial part of the plant. Other alkaloids are
extracted from Glaucium flavum: coridine,
isocoridine, isoboldine etc.

Uses. Glaucin has cough soothing action,
which is stronger and longer of that of
codeine and does not have narcotic effect.
Medicines glaucinum hydrochloridum,
glauvent and broncholytin reduce cough and
are used in treatment of bronchitis,
pneumonias and different diseases of
bronchial tubes and lungs.
Herba Macleayae
Macleaya cordata- Plume poppy
Papaveraceae

Constituents. The plant
contains isoquinoline alkaloids
(0.7-1.5%): alocryptopine,
sanguinarine, khelleritrine,
protopine, berberine.

Uses. Sanguiritrine has
antimicrobial action against
gram-positive bacteria, has
antitrichomonadal activity. Also
is used to treat cerebral palsy in
children, miopathia and paresis.
Herba Chelidonii
Chelidonium majus- Greater celandine
Papaveraceae
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Constituents. Greater celandine
contains up to 4% of alkaloids
including α- and β-allocryptopine,
berberine, chelerythrine,
chelidonine, chelirubine, choline,
coptisine, hydroxychelidonine, and
others.
Uses. The drug has many
traditional uses based on its
reputed anodyne, antispasmodic,
caustic, diaphoretic, diuretic,
hydragogue, narcotic and
purgative properties. It also has
fungistatic and bacteriostatic actin
on TB agents. Juice from fresh
herb or roots can be used to treat
throat warts.
Folia Berberidis
Radices Berberidis
Berberis vulgaris- Barberry
Berberidaceae

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Constituents. The main alkaloid
is berberin (up to 1.5% in roots).
Plant also contains palmatin,
columbamine, yatroricine,
oxicantine and khelidonic acid,
polysaccharides, carotinoids,
antocyanes, ascorbic acid etc.
Uses. Berberinum bisulphate
(from roots) has holagogue action
and used to treat chronic hepatitis
and cholelithiasis. Tincture from
leaves has tonic action on womb
muscles after delivery.
Tubera cum radicibus Stephaniae glabrae
Stephania glabra
Menispermaceae
Constituents. The main
alkaloids are gindarine (up
to 30% of all alkaloids) and
stepharine.
 Uses. Gindarinum
hydrochloride is tranquiliser
and is used to treat CNS
diseases, has sedative, light
hypnotic effect and
hypotensive action.

Folia Ungerniae victoris
Ungernia victoris
Amaryllidaceae
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Constituents. Leaves contain
alkaloids of galantamine and
likorine type. The main are
galantamine, galantine, likorine
(0.05-0.1%).
Uses. Galantaminum
hydrobromide is used to treat
miasthenia, radiculitis, cerebral
palsy. Likorinum hydrochloride
has broncholitic action and is
used as expectorant.