Transcript Blood Typing

Topic: Blood Typing
What is the ABO system?
Genetics of Blood Typing
• Multiple alleles- one gene with more than
2 allele forms
• AA or Ai = type A
• BB or Bi = type B
• AB= type AB (codominance)
• ii = type 0
Blood
Type
Antigens
On Red
Blood
Cells
Antibody
In
plasma
May
Donate
To:
May
Receive
From:
A
A
Anti-B A, AB O, A
B
B
Anti-A B, AB O, B
AB
Both
None
AB
O
None
Both
O, A,
B, AB
O, A,
B, AB
O
What happens if you mix the
wrong blood types?
• The antibodies made will stick to
the red blood cells and cause
clumping.
• The clumping is called
agglutination.
The Rh Factor
• Humans may have a second antigen
present on red blood cells.
• Most likely caused by dominant gene
• If you have it , you are Rh (+)
• If you don’t have it, you are Rh (-)
Rh disease
• Happens when mom is Rh- and dad is
Rh+
• If baby is Rh+, mom will produce Rh
antibodies.
• First baby may be OK, but second????
• Treatment: Drug called Rhogam.