Transcript Document

Lecture 24
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Regulation
Regulation
Carbons for amino acids
Amino acids = More than proteins!
Creatine
Glutathione
Heme
Nitric oxide
Hormones
Neurotransmitters
Nucleotide synthesis from many molecules
Synthesis of purines…
…starts on a ribose molecule
A & G from I
Regulation of purine synthesis
Pyrimidine biosynthesis
Regulation
Regulation
In the presence of CTP, enzyme changes:
A. No change in kinetic parameters
B. Vmax increases
C. Km increases
D. Vmax decreases, Km increases
E. Vmax decreases, Km increases, kcat increases
Nucleotide metabolism…
Still have a MAJOR question…
A. Source of C and N for Pu and Py rings
B. Regulation of synthesis
C. NTP  dNTP
D. NMP  NTP
E. Difference between plants & animals
Oxy  deOxy
Regulation by reduction!
Regulation of ribonucleotide reductase
The deal with THF