Transcript Chemical Synthesis

Chemical Synthesis
Lesson 4
Learning objective: To understand the
stages involved and techniques used
when planning a chemical synthesis.
• Must: Know the stages and techniques used
during a chemical synthesis.
• Should: Be able to make a soluble salt.
• Could: Explain all the stages and techniques
used.
• Keywords: Synthesis, techniques, plan
reactant and product.
Why do new medicines need to be
developed?
Combinational chemistry.
• Discover:
• Watch the following
short clip about the
development of a new
drug.
• http://www.youtube.co
m/watch?v=oisCUrYbx2
Q&safe=active
• Pay particular attention
to the stages involved in
the development.
What are the stages in a chemical
synthesis?
Rearrange these and note in your exercise book with
a justification for each stage
• 1. Separate product from reaction mixture.
• 2. Work out quantities of reactants needed.
• 3. Purify the product.
• 4. Risk assessment.
• 5. Choose suitable equipment and reaction
conditions.
• 6. Measure yield and check purity.
• 7. Choose the reaction or series of reactions.
Experimental techniques - NHT.
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What do these techniques do?
1. Dissolving.
2. Filtration.
3. Evaporation.
4. Crystallisation.
5. Drying in oven or dessicator.
Testing understanding.
• Complete the questions on slides five and six
• Write a day (or two) in the life of a molecule
involved in the synthesis of a new drug. You
should be one of the starting reagents and still
be present in the finished drug. Describe the
whole process from slides 3-6 from the
molecules point of view. Two sides of A4. All
red words must be defined.
• EXT- Describe in 100 words or less how this
new drug will be tested. Spectroscopy and
medical trials should feature.