Transcript ORGANIC AND PHARMACEUTICAL LAB

ORGANIC AND
PHARMACEUTICAL LAB
Pharmacy faculty
2013 – 2014
Chapter 4
Course of study
Synthesis studies
Work-up(purification) studies
Yield calculation
Literature search
Sources to obtain chemicals
Qualitative and quantitative analysis
Instrumental analysis (introductory level)
Introduction
Organic Chemistry research involves the synthesis of
organic molecules and the study of their reaction paths,
interactions, and applications. Advanced interests
include diverse topics such as the development of new
synthetic methods for the assembly of complex organic
molecules and polymeric materials, organometallic
catalysis, organocatalysis, the synthesis of natural and
non-natural products with unique biological and
physical properties, structure and mechanistic analysis,
natural product biosynthesis, theoretical chemistry and
molecular modeling, diversity-oriented synthesis, and
carbohydrate synthesis.
Synthesis studies
Organic compounds that has been never
synthesis before
Strategy:
Pharmaceutical chemistry research studies
on the design and synthesis of novel drug
candidate molecules is a good representative
example to this category
Organic compounds that has been synthesis
previously
Strategy:
In these synthesis types is the discover of a
novel synthetic approach that supplies high
yields and the lowers the synthesis cost
Work-up and purification
studies
Work-up
Purification
Which factors are important in
work-up
Reaction condition
Reaction yield
Chemical and physical properties(reactants,
regents, products)
Number of products and reactants
Yield calculation
Mechanism of acetophenone
Literature search
Why literature is very important?
Notice:
An effective literature search must be
performed before making a practice in
laboratory
Sources to obtain chemicals
Qualitative and quantitative analysis
Instrumental analysis-structure
identification (Brief introduction)
High performance liquid chromatography (HPLC)
Ultra performance liquid chromatography(UPLC)
Mass spectroscopy (MS)
Infrared spectroscopy (IR)
Ultraviolet spectroscopy (UV)
High performance liquid chromatography
(HPLC)
Ultra performance liquid chromatography
(UPLC)
Qualitative and quantitative measurement
Gas chromatography-Mass
spectroscopy (GC-MS)
Infrared spectroscopy (IR)
Ultraviolet spectroscopy (UV)