Transcript Slide 1
Computational Biology Research Group Department of Microbiology, University of Washington, Seattle http://www.compbio.washington.edu/ Instructions: The genetic code is the set of rules by which information encoded in genetic material (DNA or RNA sequences) is translated into proteins (amino acid sequences) by living cells. Specifically, the code defines a mapping between trinucleotide sequences called codons and amino acids. For a given codon (3 nucleotide sequence) to find the amino acid coded 1.Start with the first nucleotide center blue circle 2.Follow the second nucleotide from red circle 3.Follow the third nucleotide from green circle AAA codes for the amino acid Lysine (K) Example: GGU GAA AAU GAG ACU AUU UGU G E N E T I C --- --- --- --- --- --- --- CRACK THE FOLLOWING CODES ACC AGG GCU AAU AGU UUA GCG ACU AUC ... AAC T R A N S L A T I O N 1. --- --- --- --- --- --- --- --- --- --- --- m-RNA base Codons ... AUA ... AUU AAC UUC ... CGG AUG GCA ACG AUU UGU UCA B I O I N F O R M A T I C S 2. --- --- --- --- --- --- --- --- --- --- --- --- --- --UUU ... UUG GAC AUA AAU GGG F O L D I N G 3. --- --- --- --- --- --- --- CCU AGG AUC ... AAC P R I O N 4. --- --- --- --- --- Instructions: Amino acids are the structural units that make up proteins. They all have different atomic composition and thus structures. Using the table on the right decipher the following protein hieroglyphs. P A S I F I C P A S I F I C ___________________ S C I E N C E ___________________ C H A R L E S ______________________ F R A N C I S ______________________ R I C H A R D ______________________ For online version visit: C E N T E R _______________ D A R W I N _________________ C R I C K ________________ F E Y N M A N ____________________ http://protinfo.compbio.washington.edu/prostring/ Alanine Ala A Arginine Arg R Asparagine Asn N Aspartic acid Asp D Cysteine Cys C Glutamic acid Glu E Glutamine Gln Q Glycine Gly G Histidine His H Isoleucine Ile I Leucine Leu L Lysine Lys K Methionine Met M Phenylalanine Phe F Proline Pro P Serine Ser S Threonine Thr T Tryptophan Trp W Tyrosine Tyr Y Valine Val V Computational Biology Research Group Instructions: Department of Microbiology, University of Washington, Seattle http://www.compbio.washington.edu/ Write your name in both sections A and B and translate it into the “Genetic Code” and the “Protein Hieroglyph”. When you finish let us check it… ____________________________________________ ____________________________________________