Transcript PP Presentation

Winning at Weight Loss
Fatless®
1
H
o
n
i
l
Fatless®
Carbohydrates and Weight Gain
• Carbohydrate consumption has increased over the
years as fat intake has decreased.
• Obesity and diabetes rates have risen along with
carbohydrate consumption.
• A typical Western diet provides:
– 200-300g carbohydrates/day
– 900-1350 calories
– 49% of total calories from carbohydrates
• Blocking the conversion of carbohydrates into
glucose can reduce fat storage and promote weight
loss.
2
H
o
n
i
l
Fatless®
“Potatoes, eaten in large quantities
by a population increasingly
sedentary and overweight, may be
a major contributor to America’s
alarming rates of heart disease and diabetes.”
Time Magazine, Jan. 21, 2002
“10 Foods That Pack A Wallop”
3
H
o
n
i
l
Fatless®
“This is not just a potato
problem. It’s also a
problem with white bread,
bagels, and most white rice.”
Time Magazine, Jan. 21, 2002
“10 Foods That Pack A Wallop”
4
H
o
n
i
l
Fatless®
Carbohydrates and Weight Gain
Liver
Pancreas produces alpha amylase,
a starch-digesting enzyme
Alpha amylase converts starch
Stomach
into glucose (sugar)
Pancreas
Small
Intestine
Sugar calories are burned or stored as fat
cells
5
H
o
n
i
l
Fatless®
Foods Containing Starchy Carbohydrates
•
•
•
•
•
Potatoes
Pasta
Bread
Rice
Grain
Refined and processed grains have a high
glycemic index
6
H
o
n
i
l
Fatless®
Health Risks of Obesity
•
•
•
•
•
•
•
•
•
Hypertension
Hyperlipidemia
Coronary Artery Disease and Stroke
Type 2 Diabetes
Respiratory Disease (sleep apnea)
Osteoarthritis
Gallbladder disease
Cancer (breast, prostate, colon)
Premature Death!
7
H
o
n
i
l
Fatless®
Why Is The Incidence Rising?
• Lack of physical activity
• Poor dietary choices (convenience foods)
– Fast food, processed food, and sugar rather than whole
grains and vegetables
• Increased caloric intake
– Increased consumption of grains, soft drinks (sugar)
and alchohol1
Center for Nutrition Policy and Promotion, USDA, 2001
8
H
o
n
i
l
Fatless®
Many People Need A Kick Start
• Lifestyle Coach
• Dietitian
• Nutritional Supplements
• Prescriptions Drugs (for severe cases)
9
H
o
n
i
l
Fatless®
• The first clinically studied starch neutralizer
• Standardized extract made from a portion of the
white kidney bean
• Fatless® may bind with alpha amylase,
“neutralizing” starch calories and preventing the
conversion into glucose (sugar)
10
H
o
n
i
l
Fatless®
In Vitro Studies
• One gram of Fatless® will “neutralize the starch
calories of 1 lb. pasta or 1 loaf bread
• High Activity
Fatless® : 5,000 – 6,000 units/g
Non-standardized bean "starch blocker”:
0-540 units/g
• No trypsin/protein inhibitor activity detected
• Survives undiluted gastric and intestinal solutions
(68-80% retention of activity)
11
H
o
n
i
l
Fatless®
Human Studies
1. “In Vivo Effectiveness of a Starch Absorption Blocker in a Double-Blind
Placebo-Controlled Study with Normal Human Subjects.” Joe A. Vinson, PhD,
University of Scranton, September/2001
2. “In Vivo Effectiveness of a Starch Absorption Blocker in a Double-Blind
Placebo-Controlled Study with Normal College-Age Subjects.” Joe A. Vinson,
PhD, University of Scranton, November/2001
3. “Evaluation of the Safety and Efficacy of a Food Supplement for Weight Control
Through the Reduced Calories Intake from Carbohydrates vs Placebo (Double
Blind Test).” Dr. R. Ballerini, EVIC Italia, November/2001
4. “Dose-Response Pilot Study of PHASEOUT efficacy as an inhibitor of glucose
absorption with a Full Meal.” Joe A. Vinson, PhD, University of Scranton, May
2002.
5. “Phaseolamin 2250™ (Phaseolus vulgaris) for the Treatment of Obesity.” Jay
Udani, MD, Northridge Hospital, 2002
6. “Dose Response Human Study of Amylase Inactivator with Normal Subjects
Given a Full Meal.” Joe A. Vinson, PhD, University of Scranton, 2002
12
Fatless®
H
o
n
i
l
Weight Loss Study
Dr. R. Ballerini, EVIC, Milan, Italy, November/2001
• 60 subjects, ages 25-45 (male & female, 5-15 kg
overweight, stable for 30 days prior to study)
• Double-blind, placebo-controlled study for 30 days
• Recommended diet with daily consumption of complex
carbohydrates during one of the principal meals
• Experimental: Placebo plus 500 mg of a Fatless®
containing product.
• Changes in weight; fat and lean body mass (bioelectric
impedance); waist, hip, and thigh circumference
13
H
o
n
i
l
Fatless®
Results – Ballerini Study
Fatless®
Placebo
-2,933 kg
-0.348 kg
-6.45 lbs
-0.76 lbs
-3.96% TBW
-0.47%
-10.45%
-1.30%
0.0%
0.0%
Hip Circumference
-1.39%
-0.10%
Thigh Circumference
-1.44%
-0.39%
Waistline Circumference
-3.44%
-0.53%
Weight
TBW
Fat Body Mass
Lean Body Mass
14
H
o
n
i
l
Fatless®
NORTHRIDGE HOSPITAL
• Randomized, Double-Blind, Placebo Controlled
• 50 Patients
– Obese (35 > BMI > 30)
– Age < 50
– Based on Statistical Effect Size Calculation
• 8 week active study
• 1500mg of Fatless® or Placebo
Approved by Human Use and Research Committee
15
H
o
n
i
l
Fatless®
Overall Results
Fatless®
•
•
•
•
•
3.8 pounds
1.5 inches off waist
26 point drop TG
13%  energy
Reduced hunger
•
•
•
•
Placebo
1.1 pounds
No loss of inches
8 point drop TG
No effect on energy or
hunger
16
H
o
n
i
l
Fatless®
Summary
• Natural, standardized extract with the first
demonstration of effectiveness in human studies
• Safe, non-stimulant carbohydrate control
mechanism that blocks carbohydrate conversion to
sugar calories
• Reduces starch absorption by an average of 57%
• Produces weight loss by reduction of body fat mass
• No known adverse side effects or drug interactions
• Reasonable effective doses (500-1,500 mg/meal)
17
The bottom line…
Healthy eating and physical
activity are essential for weight
management.
18