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Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell–mediated elimination of tumor cells by Joseph S. Palumbo, Kathryn E. Talmage, Jessica V. Massari, Christine M. La Jeunesse, Matthew J. Flick, Keith W. Kombrinck, Markéta Jirousková, and Jay L. Degen Blood Volume 105(1):178-185 January 1, 2005 ©2005 by American Society of Hematology Gαq–/– platelets fail to support thrombus formation in vivo. Joseph S. Palumbo et al. Blood 2005;105:178-185 ©2005 by American Society of Hematology Gαq deficiency dramatically diminishes the metastatic potential of circulating tumor cells. Joseph S. Palumbo et al. Blood 2005;105:178-185 ©2005 by American Society of Hematology Gαq expression within hematopoietic-derived cells is a major determinant of metastatic potential. Joseph S. Palumbo et al. Blood 2005;105:178-185 ©2005 by American Society of Hematology Platelet activation is a significant determinant of spontaneous metastasis but not tumor growth. Joseph S. Palumbo et al. Blood 2005;105:178-185 ©2005 by American Society of Hematology Platelet activation supports tumor cell survival in the lungs via a mechanism coupled to NK cell function. Joseph S. Palumbo et al. Blood 2005;105:178-185 ©2005 by American Society of Hematology Fibrin(ogen) supports tumor cell survival in the lungs by a mechanism coupled to NK cell function. Joseph S. Palumbo et al. Blood 2005;105:178-185 ©2005 by American Society of Hematology