Transcript Powerpoint - Blood Journal

Priming innate immune responses to infection by
cyclooxygenase inhibition kills antibiotic-susceptible and resistant bacteria
by Melanie J. Stables, Justine Newson, Samir S. Ayoub, Jeremy Brown, Catherine J.
Hyams, and Derek W. Gilroy
Blood
Volume 116(16):2950-2959
October 21, 2010
©2010 by American Society of Hematology
Characterization of infectious peritonitis.
Melanie J. Stables et al. Blood 2010;116:2950-2959
©2010 by American Society of Hematology
COX1 is the predominant isoforms functional during infectious peritonitis.
Melanie J. Stables et al. Blood 2010;116:2950-2959
©2010 by American Society of Hematology
COX inhibition enhances bacteria killing in rodents.
Melanie J. Stables et al. Blood 2010;116:2950-2959
©2010 by American Society of Hematology
COX inhibition alters phagocytosis, cytokine synthesis, and bacterial killing mechanisms in a
cAMP-dependent manner.
Melanie J. Stables et al. Blood 2010;116:2950-2959
©2010 by American Society of Hematology
Prophylactic but not therapeutic COX inhibition triggers pro-inflammatory cytokine synthesis.
Melanie J. Stables et al. Blood 2010;116:2950-2959
©2010 by American Society of Hematology
COX inhibition primes human whole blood to kill bacteria.
Melanie J. Stables et al. Blood 2010;116:2950-2959
©2010 by American Society of Hematology
Inhibiting PG signaling primes human whole blood to kill antibiotic-resistant bacteria.
Melanie J. Stables et al. Blood 2010;116:2950-2959
©2010 by American Society of Hematology