Transcript Powerpoint - Blood Journal

Acquired α-thalassemia in association with
myelodysplastic syndrome and other hematologic
malignancies
by David P. Steensma, Richard J. Gibbons, and Douglas R. Higgs
Blood
Volume 105(2):443-452
January 15, 2005
©2005 by American Society of Hematology
Schematic representation of the human globin gene clusters.
David P. Steensma et al. Blood 2005;105:443-452
©2005 by American Society of Hematology
Typical blood findings in ATMDS. (A) Peripheral blood smear (May-Grünwald-Giemsa) from a
patient with ATMDS who had not undergone transfusion.
David P. Steensma et al. Blood 2005;105:443-452
©2005 by American Society of Hematology
Distribution of red blood cell indices in patients with α-thalassemia MDS (ATMDS) compared
with a more general population with MDS. (A) MCV in ATMDS (n = 55) and MDS (n = 282) patients.
David P. Steensma et al. Blood 2005;105:443-452
©2005 by American Society of Hematology
Schematic representation of the spectrum of ATRX mutations that have been described in boys
with ATR-X syndrome with those found in ATMDS. The ATRX gene (top, with introns not to scale)
is aligned with ATRX protein (bottom) to allow comparison of the mutat...
David P. Steensma et al. Blood 2005;105:443-452
©2005 by American Society of Hematology
Immunofluorescence results.
David P. Steensma et al. Blood 2005;105:443-452
©2005 by American Society of Hematology
Distribution of the proportion of HbH in the peripheral blood in ATMDS compared with ATR-X
syndrome.
David P. Steensma et al. Blood 2005;105:443-452
©2005 by American Society of Hematology
Model for how ATRX might influence gene expression.
David P. Steensma et al. Blood 2005;105:443-452
©2005 by American Society of Hematology