Transcript Powerpoint - Blood Journal

Mast cell activation contributes to sickle cell pathobiology
and pain in mice
by Lucile Vincent, Derek Vang, Julia Nguyen, Mihir Gupta, Kathryn Luk, Marna E.
Ericson, Donald A. Simone, and Kalpna Gupta
Blood
Volume 122(11):1853-1862
September 12, 2013
©2013 by American Society of Hematology
Mast cell activation occurs in sickle cell anemia.
Lucile Vincent et al. Blood 2013;122:1853-1862
©2013 by American Society of Hematology
Mast cell activation contributes to neuro-inflammation in SCA. (A-K) HbSS-BERK mice were
treated with saline (Veh), CS, or imatinib mesylate (Imat) for 5 days followed by analysis as
indicated with each figure.
Lucile Vincent et al. Blood 2013;122:1853-1862
©2013 by American Society of Hematology
Neurogenic inflammation occurs in SCA. (A-B) Evans blue leakage evoked by injection of saline,
capsaicin, or SP in the hind paws (A) and dorsal skin (B) of mice treated with vehicle (saline),
morphine sulfate (MS, 10 mg/kg), CS (100 mg/kg), or imatinib (Ima...
Lucile Vincent et al. Blood 2013;122:1853-1862
©2013 by American Society of Hematology
Mast cells contribute to hyperalgesia in SCA. (A-D) HbSS-BERK mice were treated with vehicle
(Veh), CS, or imatinib (Imat).
Lucile Vincent et al. Blood 2013;122:1853-1862
©2013 by American Society of Hematology
Mast cell activation contributes to hypoxia/reoxygenation-induced pain in SCA. (A-C) HbAA- and
HbSS-BERK mice were treated with saline (Veh) or imatinib (imat) for 5 days.
Lucile Vincent et al. Blood 2013;122:1853-1862
©2013 by American Society of Hematology
Activated mast cells contribute to a feed-forward cycle of neuropeptide release in the skin of
sickle mice.
Lucile Vincent et al. Blood 2013;122:1853-1862
©2013 by American Society of Hematology