Transcript Human Papillomavirus (HPV)

Human Papillomavirus (HPV)
Wed, Nov 21 2007
Tanjung Jaya, Indonesia
The Virus
• Papovaviridae
• infect skin and mucous membrane
• entry through clathrin mediated
endocytosis to basal epithelia from
micro-abrasions
Epidemiology
• modes of transmission is skin to skin,
mucous membrane contact
• perinatal transmission (rare) causing
respiratory papillomatosis
• 45% women at age 20-24, anyone
sexually active is at risk
HPV types
• >100 subtypes, 30-40 STD
• high-risk type HPV 16, 18, 35, 45 –
leads to cervical, vulva, vaginal cancer
and other genitalia cancer including
in men
• low-risk type HPV 6, 11 –causes
genital warts
• cutaneous HPV 1,2 –skin warts
• HPV type 16 and 18 cause nearly 70%
of cases of cervical cancer
• HPV type 6 and 11 cause approx. 90%
of genital warts
• Both 4 types cause 35-50% of all low
grade cervical, vaginal and vulvar
lesions
Diagnosis
• abnormal PAP smear
• HPV DNA testing (problemexpensive, cannot distinguish active or
latent)
• acetic acid-warts more visible
Treatment and Prevention
• common skin and genital warts will
regress spontaneously/ months/
years due to immune response
• common warts also can be eliminated
using lasers
• vaccine Gardasil from Merck –
approved June 2006 and Cervarix from
GlaxoSmithKline –approved May 2007
• ‘trick’ body into thinking that there is
HPV infection thus generates immune
response
• vaccine does not cure HPV, it prevents
thus not suitable for infected patient,
but not 100% prevention
• best prevention = vaccine + PAP
smear annually (depends)
HPV in Malaysia
• cervical cancer is 2nd most common
cancer in women
• Gardasil has been approved during
October 2006
• MSD collaborate with OGSM to
spearhead ‘Tell Someone’ campaign
• small figures for those who undergoes
PAP smear each year
Reference
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HPV
http://alpha.montclair.edu/~Williamss4/diagnosis.htm
http://udel.edu/~jlaverty/Human%20Papilloma%20Virus.html#Pathogene
sis__Symptoms
http://en.wikipedia.org/wiki/Human_papilloma_virus#HPV_testing
Cervical cancer is preventable 2007
http://www.redorbit.com/news/health/884330/cervical_cancer_is_preventa
ble/index.html
‘Tell Someone’ campaign in Malaysia
http://www.msdmalaysia.com/content/corporate/about/news/2007/TellSomeone.html
Indonesia ‘Tree Man’
http://news.yahoo.com/s/nm/20071122/lf_nm_life/indonesia_tree_man_d
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