Transcript Human Papillomavirus(HPV)

A non-enveloped DNA
virus which infects
the skin/ mucous
membranes of humans
Icosahedral, non-enveloped, circular
DNA
 E6 and E7 proteins inactivate tumor
suppressor gene (P53, RB)

Malignant: viral DNA integrated to host
DNA
 Nonmalignant: viral DNA is episomal

Skin contact
 Sexual Contact

20 million People in America today are
infected with HPV

100+ forms of HPV

Low Risk: cause warts on the mouth,
anus, vagina, vulva, penis and thighs
 High
Risk: can lead to cancer of the
cervix, anus, and other genital areas

50% of sexually active people will
contract some form of the virus in their
life

90% of the time the virus will go away on
its own

Most don’t know they ever had HPV

A Pap Smear is the only way to detect
cervical cancer in its early stages
This is a Pap smear
showing normal
cervical cells. Millions
of women aren’t as
lucky!
Abstinence
 Condom use
 Gardasil (protects against 4 types of
HPV)
