Transcript Selective Inner Hair Cell Loss in Premature Infants and Cochlea

From: Selective Inner Hair Cell Loss in Premature Infants and Cochlea Pathological Patterns From Neonatal
Intensive Care Unit Autopsies
Arch Otolaryngol Head Neck Surg. 2001;127(6):629-636. doi:10.1001/archotol.127.6.629
Figure Legend:
Normal organ of Corti from the upper middle turn of a cochlea showing excellent preservation. From patient 15, a full-term baby who
passed the auditory brainstem response screening on day 6 and died on day 8. Note stereocilia of the inner hair cell (short arrow)
and outer hair cells (long arrows) (hematoxylin-eosin, original magnification ×250).
Date of download: 4/3/2017
Copyright © 2017 American Medical
Association. All rights reserved.
From: Selective Inner Hair Cell Loss in Premature Infants and Cochlea Pathological Patterns From Neonatal
Intensive Care Unit Autopsies
Arch Otolaryngol Head Neck Surg. 2001;127(6):629-636. doi:10.1001/archotol.127.6.629
Figure Legend:
Photomicrographs illustrating expected selective outer hair cell (OHC) loss (long arrows) in 2 patients. Short arrows in both parts
indicate stereocilia on inner hair cells. A, All 3 OHC rows are missing in this section from the basal turn of patient 1, a full-term baby
who failed the auditory brainstem response screening on days 4 and 7 and died on day 8. B, The first 2 rows of OHCs are missing in
this section from the middle turn of patient 2, a full-term baby who failed the auditory brainstem response screening on days 1, 3,
and 15 and died on day 18 (both parts hemoxylin-eosin,
×250).
Copyrightoriginal
© 2017 magnification
American Medical
Date of download: 4/3/2017
Association. All rights reserved.
From: Selective Inner Hair Cell Loss in Premature Infants and Cochlea Pathological Patterns From Neonatal
Intensive Care Unit Autopsies
Arch Otolaryngol Head Neck Surg. 2001;127(6):629-636. doi:10.1001/archotol.127.6.629
Figure Legend:
Cytocochleograms for left and right ears in the 2 patients showing selective outer hair cell (OHC) loss. The 3 OHC rows and 1 inner
hair cell (IHC) row are indicated by different symbols (see key). Each point represents the percentage of missing hair cells for that
row, as averaged across all sections within consecutive 1-mm lengths of organ of Corti. Cochlear location is converted to frequency
via Schuknecht's map. The most critical frequencies for hearing speech are approximately 0.5 to 4 kHz, similar to the stimulus
bandwidth tested by the auditory brainstem response
screener.
Copyright
© 2017 American Medical
Date of download: 4/3/2017
Association. All rights reserved.
From: Selective Inner Hair Cell Loss in Premature Infants and Cochlea Pathological Patterns From Neonatal
Intensive Care Unit Autopsies
Arch Otolaryngol Head Neck Surg. 2001;127(6):629-636. doi:10.1001/archotol.127.6.629
Figure Legend:
Photomicrographs illustrating selective inner hair cell (IHC) loss in 2 premature infants. In both parts, the absent IHC is indicated by
the large arrow, and the outer hair cells are indicated by the small arrows. A, From the basal turn of patient 3, an infant of 30 weeks'
gestation who failed the hearing test on days 19 and 21 and died on day 24. B, From the midbasal turn of patient 4, an infant of 31
weeks' gestation who passed the hearing test on days 2 and 6, failed on days 8 and 10, and died on day 12 (both parts,
hematoxylin-eosin, original magnification ×250).Copyright © 2017 American Medical
Date of download: 4/3/2017
Association. All rights reserved.
From: Selective Inner Hair Cell Loss in Premature Infants and Cochlea Pathological Patterns From Neonatal
Intensive Care Unit Autopsies
Arch Otolaryngol Head Neck Surg. 2001;127(6):629-636. doi:10.1001/archotol.127.6.629
Figure Legend:
Cytocochleograms for right and left ears in the 3 infants showing selective inner hair cell (IHC) loss. All other conventions for data
display are as described in the legend to Figure 3.
Date of download: 4/3/2017
Copyright © 2017 American Medical
Association. All rights reserved.
From: Selective Inner Hair Cell Loss in Premature Infants and Cochlea Pathological Patterns From Neonatal
Intensive Care Unit Autopsies
Arch Otolaryngol Head Neck Surg. 2001;127(6):629-636. doi:10.1001/archotol.127.6.629
Figure Legend:
Spiral ganglion cell counts in each ear from 14 of 15 patients in the present study plotted as a function of postconceptional age.
(Data from patient 6 with trisomy 13 is not included). The cell counts are expressed as a percentage of the mean neuronal counts
found in a study of temporal bones from older patients (adapted from Otte et al).
Date of download: 4/3/2017
Copyright © 2017 American Medical
Association. All rights reserved.