Transcript F13Lect23AIDS

Bio 328 Immunology
AIDS
Dr. Jay Levy: first descriptions of AIDS 1981.
Luc Montagnier
Robert Gallo
Peter H.
Duesberg
Duesberg & Yiamouyiannis p1
China
Zimbabwe household
Agnes Dlamini, 81, with her orphan grandchildren Lindelani, 9, and
Tipho, 13, on their street. Alexandra township, Johannesburg, South
Africa; August 2012. (Time 3 December 2012 p16-18.)
Mary Mokhethoa,68, with her three orphan grandchildren Itumeleng, 12,
Dikeledi, 20, Lebogang, 22, and her great-granddaughter, Keamogetswe.
Alexandra township, Johannesburg, South Africa; October 2012.
Maria Mokoena, 62, with her seven orphan grandchildren. Alexandra
township, Johannesburg, South Africa; October 2012.
In 2003, Mokoena began taking care of grandchildren Ernest, now 21, and Lebusa,
now 17, after her eldest daughter died of HIV/AIDS. This May, her second daughter
also died of the disease, leaving her to raise five more grandchildren.
Francina Moloi, 56, with her twin orphan granddaughters, Thuli and
Thulisile, 16, and her one-year old great-grandchild, Mthobisi, in front
of their one-room house. Alexandra township, Johannesburg, South
Africa; October 2012.
Time 3 December 2012 p16-18.
Violet Mamogobo, 56, with her granddaughter Lerato, 12, in front of their house.
Alexandra township, Johannesburg, South Africa; September 2012. When her
daughter died of AIDS in 2006, Mamogobo didn't know anything about HIV. "I
thought she was sick because of stress," she says. Mamogobo now takes care of
her HIV-positive son, as well as her granddaughter.
Fall 2015
Gaetan Dugas “Patient 0”
(1984)
David Carr, sailor (apprentice printer) of
Manchester, died at 25 of pneumonia of
unidentified cause.
1990 HIV isolated from preserved tissue of
David Carr by Dr. Gerald Corbitt, director
of Clinical Virology of Manchester Royal
Infirmary.
David Ho (1995): sequencing of the CarrHIV isolate; testing samples of kidney and
bone marrow tissue of David Carr.
1. Colonization, forced labor and
increased demands for meat.
2. Colonization and mass
displacement of labor.
3. Colonization, charity, and
curative and preventative
treatment of infectious
disease (sleeping illness,
malaria, venereal diseases) by
IV injection and reuse of
needles and syringes.
4. Independence and chaos:
urban prostitution.
5. Stabilization of Africa by UN
soldiers and export of HIV to
Haiti.
6. Haitian blood product
industry and export of HIV:
globalization.
Lentiviruses
Bovine
Bovine immunodeficiency virus
Jembrana disease virus
Equine
Equine infectious anemia virus
Feline
Feline immunodeficiency virus
Ovine
Visna.maedi virus
Caprine
Caprine arthritis encephalitis virus
Simian
Simian immunodeficiency virus
Human
Human immunodeficiency virus (HIV) 1-3
Human T-cell lymphotropic virus
Simian AIDS retrovirus SRV-1
Inhibition of infection by CCL3L1
Anti-HIV therapy
HIV
CD8+
HLA-tetramers used to
quantify early anit-HIV Tcell responses.
Nucleotide Reverse
transcriptase inhibitor.
Non-nucleotide Reverse
Transcriptase Inhibitor.
Three-year treatment with Idinavir,
zidovudine, lamivudine
Proportion of patients with serum
HIV RNA <50 copies/ml)
Thimothy Ray Brown
“Berlin Patient”
Matt Sharp
“Patient 01-203
CCR5-D32 (deletion 794-825)
CCR5 D32 allele frequency.
The End