Transcript Heliobacter pylori - University of Louisville

D. Brown F2013
Modified by DYH
Heliobacter pylori
• Gram negative bacterium
• Helix-shaped
• Commonly linked to stomach ulcers
• Facultative aerobe
• May contain pathogenicity islands
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Contain the cagA gene which contributes in the
formation of stomach ulcers.
• They are found in the upper respiratory tract of
more than 50 % of people in the world
• Genome is 1.7 Mbps, containing around 1550
genes.
http://bioweb.uwlax.edu/bio203/s2008/pluym_evan/
D. Brown F2013
Modified by DYH
Heliobacter pylori
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Uses it flagella to dig through the stomach lining to reach
the epithelial cells
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Forms adhesins which bind to epithelial cell membrane’s
lipids and carbohydrates
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To regulate pH, it produces ammonia, which is toxic to
epithelial cells
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After attachment, the Type IV secretion system injects
peptidoglycan and CagA protein into the epithelial cells,
which promotes inflammation and disrupts the
cytoskeleton, respectively.
http://www.nature.com/nrmicro/journal/v2/n9/fig_tab/nrmicro955_F3.html
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There are a few strains where antibiotic resistance has
recently occurred.