Transcript Streptobacillus moniliformis “Rat

Streptobacillus moniliformis
M. Piechowski F2013
Modified by DYH
“Rat-Bite Fever”
The Microbe:
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Pleomorphic (rod, filamentous); typically arranged in
chains
Variable in size: 0.1 to 0.5 um up to 10 to 15 um.
Gram-negative
Nonmotile
-Exists in two forms: it’s spontaneous L-form type is
considered nonpathogenic.
Extremely fastidious organism; needs
microaerophilic conditions to grow.
-Chemoorganotrophic
Facultative anaerobe; strictly fermentative
S. moniliformis seems to live natural as a member
of the commensal flora in the upper respiratory tract
of rats. (Rats are asymptomally colonized). As such,
has an optimal temperature of 35-37 degrees C.
Catalase and oxidase-negative enzymes.
Chromosome: 1.662578 Mb.
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2 Major contigs.
Molecular percentage of G+C: 24-25%
SCANNING ELECTRON MICROGRAPH OF S. MONILIFORMIS 9901
http://www.standardsingenomics.org/index.php/sigen/article/view/sigs
31#t3
AttributeValue% of Total
Genome size (bp)1,673,280100.00
%DNA coding region (bp)1,556,87093.04
%DNA G+C content (bp)439,73326.28
%Number of replicons2
Extrachromosomal elements1
Total genes1,566100.00
%RNA genes553.51%rRNA operons5
Protein-coding genes1,51196.49%
Pseudo genes694.41%
Genes with function prediction1,05467.31
%Genes in paralog clusters32120.50%
%CRISPR repeats1
Info from: http://www.standardsingenomics
.org/index.php/sigen/article/view/sigs.48727/131
http://blog.hygienesuppliesdirect.com/pest-control/get-rid-of-rats/
M. Piechowski F2013
Modified by DYH
The Disease:
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RBF is commonly transmitted from scratches or bites of infected rodents or from consuming food or
drink with the bacteria. No evidence of person-person transmission.
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The Disease characterizes symptoms of Fever, Vomiting, Headache, Sore Throat, Muscle pain, Joint
pain and Rash. Symptoms occur 3-10 days after exposure. Rash appears as maculopapular (flat,
reddened areas with small bumps) localized to hands and feet extending to extremities. If left untreated,
10% mortality rate.
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S. moniliformis virulence not well understood
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Alpha hemolysis
Hemoaglutinin
Rod form more virulent than cocci form
Treatment: antibiotics. Penicillin most used.
Wang and Wong BMC Infectious Diseases 2007 7:56 doi:10.1186/1471-2334-7-56
Complete circular genome and plasmid sequencing
http://www.standardsingenomics.org/index.php/sigen/article/view/sigs.48727/131