Transcript The Acute Phase Response

BBS3027 2000: Infectious Diseases
Dr Garwin Sing
[email protected]
http://trishul.sci.gu.edu.au/courses/bbs3027/
Gut Mucosa
Gut Mucosa
Mucosal Epithelium
Epithelial Barriers to Microbial
Infection: Physical
• Epithelial cells joined by tight junctions
• Exfoliation of surface cells
• Mucous flow by ciliated epithelia (respiratory
tract)
Epithelial Barriers to Microbial
Infection: Chemical
• Enzymes:
Lysozyme (tears, saliva, sweat)
Pepsin (stomach)
• pH:
Fatty Acids/amino acids (skin)
Gastric acids (stomach)
• Antimicrobial: Transferrin (mucus)
Epithelial Barriers to Microbial
Infection: Competition
• Gut Flora
Protection from Infectious
Agents
• Innate Immunity
• Adaptive Immunity
Fever, interferon,
neutrophils,
macrophages, NK
cells
B cells, T cells
Congenital Infections
Viruses
Anatomy
Bacteria
Physiology
Fungi
Immunity
Parasites
Commensals
Sources of Infection:
Exogenous
• Inhalation
• Ingestion
• STD
• Wound
• Insect Bite
Common cold, flu,
Legionnaire’s Disease,
Coccidioidomycosis
Typhoid fever, tapeworm,
cryptosporidium, Hepatitis A
Gonorrhea, HIV
Tetanus, Rabies
Malaria, Yellow Fever,
Dengue
Sources of Infection:
Endogenous
•
•
•
•
•
•
Gut
Skin
Tonsils
Throat
Blood
Lungs
e.g E coli
e.g. staphylococcus
e.g streptococcus
e.g. EBV
e.g Candida, CMV, streptococcus