Transcript Uridine 10% hand-foot-ointment and adhesive-paste

Uridine 10% hand-footointment and adhesive-paste
For the treatment of the hand-foot syndrome (PPE)
and mucositis induced by of 5-FU and its oral
derivates (Capecitabine, UFT)
Jürgen Barth, Essen
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The (short) story of how it came into being
• Side effects of 5-FU (& derivates):
• PPE
• Mucositis
• Pharmacological considerations about an „antidot“ in
the 90ies
• Various substances seemed to be a possibility
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Thymine
Thymidine
Uracil
Uridine
2‘-Deoxyuridine
Jürgen Barth, Essen
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The (short) story of how it came into being
• Decision: Uridine
• Development of a formula in the Dept.of Pharmacy,
Essen
• “Clinical experience“ after a short time: IT WORKS
• Since then: an “in-house-speciality”
• Useful after extravasation or skin contamination
• Uridin-Hand-Fußsalbe und Uridin-Haftpaste als effektive Antidota nach
akzidenteller Hautkontamination mit 5-Fluorouracil – ein Fallbericht
Krankenhauspharmazie 2000; 21: 625-628
• Evidence based data concerning efficacy (by
systematical inquiry): NONE
Jürgen Barth, Essen
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The formulae
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Uridine 10% hand- & foot ointment
Uridin
10 g
Propylene glycol
q.s.
Basiscreme DAC
ad 100 g
- Uridine is mixed with a small amount of propylene glycol.
- This dispersion is then added to DAC basic cream.
- DAC basic cream is monographed in the Deutscher
Arzneimittel Codex (German drug codex), representing a
collection of drug monographs besides the European and
German Pharmacopoeia.
- DAC basic cream is an amphiphile nonionic cream.
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Uridine 10% adhesive-paste
Uridin
1g
Subliquid paraffin
6,65 g
Carbopol 934
2,35 g
Spearmint oil 1 gtt.
- Uridine is added to a hydrophobic adhesive-paste
composed of subliquid paraffin and Carbopole
974P, a type of polyacrylic acid.
- The paste is flavoured with spearmint oil.
Jürgen Barth, Essen
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Aim of an ESOP study
• Systematical data collection to evaluate the efficacy
of the ointment and –if possible- the adhesive
(mucous membrane) paste
• How? ESOP will make the formulae (instructions
how to prepare a drug) available to any interested
pharmacist who feels able to prepare these
medication and offer it to physicians who treat
patients with 5-FU, Capecitabine or UFT
• Data will be collected by the individual pharmacist
• Summary and evaluation by ESOP
Jürgen Barth, Essen
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ESOP study
Evaluation sheet (and this presentation) will be
downloadable @ the ESOP homepage:
http://www.esop.li/
Jürgen Barth, Essen
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ESOP study Evaluation sheet
http://www.esop.li/
Jürgen Barth, Essen
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