Transcript Introduction to Bioelectronics - O6U E

6 October University
Faculty of Applied Medical Sciences
Department of Biomedical equipment and systems
BIOELECTRONICS 1
Lec1: Introduction to Bioelectronics
By
Dr. Eng. Hani Kasban Mahmoud
2017
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CHAPTER 1
Introduction to Bioelectronics
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Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017
Introduction to Bioelectronics
•Bioelectronics
Bioelectronics means the integration of biology with
electronic elements for building higher-level functional
devices.
Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017
Introduction to Bioelectronics
Revision (Biology)
Measured biomaterials
Cells
Proteins
Cells are the basic building blocks of all living things.
Enzymes
Large molecules that speed up the chemical reactions
inside cells. type of protein,
Proteins are one of the building blocks of body tissue,
and can also serve as a fuel source.
Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017
Introduction to Bioelectronics
Revision (Biology)
Measured biomaterials
Deoxyribonucleic Acid (DNA)
Introduction to Bioelectronics
Revision (Biology)
Measured biomaterials
The neuron (nerve cell) is the
fundamental unit of the nervous system.
The basic purpose of a neuron is to
receive incoming information and,
based upon that information, send a
signal to other neurons, muscles, or
glands. Neurons are designed to rapidly
send signals across physiologically long
distances. They do this using electrical
signals called nerve impulses or action
potentials
.
Introduction to Bioelectronics
Revision (Biology)
Measured biomaterials
Receptor
Receptor is a protein-molecule that receives
chemical-signals from outside a cell. When
such chemical-signals bind to a receptor, they
cause some form of cellular/tissue-response
Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017
Introduction to Bioelectronics
Revision (Electronics)
Electronic-Components
Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017
Introduction to Bioelectronics
Revision (Electronics)
Measured Quantities
Series
Current
Voltage
IS  I1  I 2  I 3
Parallel
I P  I1  I 2  I 3
VS = V1 + V2 + V3 VS = V1 = V2 = V3
Resistance
RS = R1+ R2 + R3
Power
PS = P1 + P2 + P3
1
1
1
1
 

RP R1 R2 R3
PS = P1 + P2 + P3
Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017
Equivalent circuit for describing the electrostatic interference.
Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017
Introduction to Bioelectronics
Bioelectronic system required the existence
of electronic coupling and communication
between the biomolecules and the electronic
supports.
Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017
Introduction to Bioelectronics
For example, the intercalation of doxorubicin (2)
into the double-stranded DNA formed between a
primer nucleic acid associated with an electrode.
Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017
Bielectronic system
Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017
Bioelectronics Applications
•Biomedical instrumentation (traditional and innovative)
based on acquisition (sensors), amplification (circuits)
and processing (systems) of electrical signals with
biological origin.
•Imaging systems for medical diagnostic employ
detectors (solid state), integrated circuits (VLSI) and
processing systems (ex. DSP) for the acquisition and the
processing of large quantities of information
•Advanced and multi-disciplinary applications of
combined electronics and biology/medicine (bio-labs on
chip, acquisition/stimulus of cellular electrical signals,
electronics prosthesis).
Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017
Bioelectronics Applications
Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017
Biopotential
Biopotential is the voltage produced by the tissue of the body,
particularly
muscle
tissue
during
a
contraction.
Electrocardiography depends on measurement of changing
potentials in contracting heart muscle. Electromyography and
electroencephalography function similarly in the diagnosis of
neuromuscular and brain disorders, respectively.
Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017
Biopotential Electrodes
Biopotential electrode is the transducer interface
between the body and the readout circuit that converts
the ionic current into electronic current, or vice versa.
Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017
Biopotential Electrodes Equivalent Circuit
CA and RA represents the impedance associated with
the electrode–electrolyte interface, and RS is the
resistance of the electrolyte solution. The half-cell
potential of the interface is represented with a voltage
source, Vhc.
Author : Dr. Eng. Hani Kasban A. Mahmoud / 2017
Questions?????
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