Transcript ANTIBODY PRODUCTION

antibody
production
SYNNOVE, KEVIN, KRIZIA
What is an
antibody?
• protein that binds to antigens
• chemicals that stimulate immune responses to
foreign proteins and molecules on the surface of
pathogens
• the body produces a vast array of different
antibodies, each one binds to a specific antigen
Where does
antibody production
occur?
In lymphocytes (white blood cells)
B-lymphocytes (or B-cells) differentiate in the bone marrow
T-lymphocytes (or T-Helper Cells) differentiate in the thymus
how are
antibodies
created?
A B Cell is trigged when it
encounters its matching
antigen.
The B-Cell engulfs the
antigen and digests it.
B
B
Antigens from the ruined pathogen are displayed
on the surface of the phagocyte (or B-cell),
bound to a membrane called MHC protein.
This combination of antigen and MHC
attracts the help of a mature, matching
Helper T Cell.
I’m a helper tcell!
B
Cytokines secreted by the Helper T cell help
the B cell to multiply and mature into
antibody producing plasma cells.
B
Antibodies are secreted.
Antibodies then lock onto matching antigens.
"AP Biology Bookmarks." Back To the
Stevenson Homepage. Web. 30 Sept. 2009.
<http://www6.district125.k12.il.us/science/AP
BIO/apwebsites.html>.
In short visual summary…
And…
So what happens after
antibodiesonto
lock
pathogens?
• pathogens more recognizable to phagocytes, so they can easily be
engulfed
• prevents viruses from docking to host cells so that they cannot be taken
up by host cells
• Causes agglutination (sticking together) of pathogens so that they are
prevented from entering cells and are easier for phagocytes to ingest.
bibliography
"AP Biology Bookmarks." Back To the Stevenson Homepage. Web. 30
Sept. 2009.
<http://www6.district125.k12.il.us/science/APBIO/apwebsites.html
Homepage - ABPI - Resources for Schools. Web. 01 Oct. 2009.
<http://www.abpischools.org.uk>.