Transcript Cell-Mediated Cytotoxicity

Cell-Mediated Cytotoxicity
Cytotoxic T-Lymphocytes
Natural Killer Cells
Antibody-Dependent, Cell-mediated
Cytotoxicity
Delayed-type Hypersensitivity
Folder Title: CellKill
Updated: November, 25, 2004
KillTitl
Cell-Mediated Immunity (CMI):
Passive transfer from donor to recipient of cells
alone, transfers the immune response function
Response to:
Neoplastic (cancer) Cells
Infected or Altered Cells
Intra-cellular Pathogens
Fungi
Allo-grafts and other transplants
CMIRoles
Cell-Mediated Immunity (CMI):
Types of Cytotoxic Cells
Antigen-Specific T-Cells (Have TCR):
Tc : Cytotoxic T-Cells
TDTH : Delayed-Type Hypersensitivity Cells
("Type IV Hypersensitivity")
Non-Antigen-Specific Cells:
Macrophages
NK Cells
Granulocytes: Neutrophils, Eosinophils, Basophils and
Tissue Mast Cells
CMICells
CTL Antigen Recognition
CD4 & CD8 Sensitize & Effect
CTL Sensitizaton Phase
CTL & MHC
Effector Phase by CTL
CTL & ICAM-1
CTL binding to
Cytotoxic T-Cell
Binding to
Target
Cell
Target
Cell
(figure 16-6,
Kuby, 3rd Edition)
TC = Target Cell for
Cytolytic T-Cell
Smaller Cell = CTL
CTLandTC
CTL Perforin Pore
T-Cell Killing by Induction of Apoptosis
(figure 16-8, Kuby, 3rd Edition)
Signals Activation
of Apoptosis
ICE = Interleukin 1
Converting Enzyme
CTL&Apop
T-Cell and NK Cell Development
Comparison of T- and NK Cells
Natural Killer Cell Targets and Restriction to Altered-Self
(Figure 16-11, Kuby, 3rd Edition)
No Killing
(Recognized Self;
MHC Class I)
Target Cell Killed
(Did not recognize self;
low MHC Class I
NKTarget
ADCC Targets
CD28 – B7 Co-stimulators
B7 Melanoma Vaccine