Transcript Tissues and Organs Comprising the Immune Response System

Tissues and Organs
Comprising the Immune
Response System
Where components of the immune response
originate,
differentiate,
meet,
interact,
and function
Folder Title: Tiss&Org
Updated: October 30, 2014
APC and T-Cells
Marcophage and T-Cell Kissing
Macrophage to T-Cell Interaction
Helper T-cell B-Cell Interaction
CD4 co-receptor
B-Cell Activation
See figure 2-7,
Kuby, 4th Ed.,
p. 36
B-Cell: Small, Blast, and Plasma
See Figure 2-7,
Kuby 4th Ed.
p. 36
Where do these cells originate?
Where do they go to interact with each other?
Where do they carry out their functions?
Related to Figure
2-13, Kuby, 4th
Edition, p. 47
Primary and Secondary
Lymphoid
Animations
Produced for Kuby Immunology
Online Link
http://bcs.whfreeman.com/immunology6e/
(In Class Do animations from the Book CD)
Chapter 2 Animation. Cells and Organs
Exactly* what kind of Cell is the one attached to the B-Cell?
*(“exactly” means not just its general type of cell, but
specifically what type of cell it is based on what this figure
shows that the cell is doing)
5000%
Rank
1
2
3
4
5
6
Responses
4500%
4000%
3500%
3000%
Other
2500%
East
West
2000%
North
1500%
1000%
500%
0%
1st Qtr
2nd
Qtr
3rd
Qtr
4th
Qtr
Thymus Photo
Thymus Cartoon
Diagrammatic Cross Section of Thymus. Figure 2-14,
Kuby, 4th Edition, p. 48
ThymusCross
CD4 and CD8 in Thymus
MALT and M-Cells
See Figure 2-22,
Kuby 4th Ed.
p. 56
MALT and IgA
See Figure 2-22
Kuby, 4th Ed.
p. 56
CD Antigen Table
CDMarks
CD Antigens Color Coded
Animations
Produced for Kuby Immunology
http://bcs.whfreeman.com/immunology6e/
Chapter 11 Animation. Signal Transduction
CD Antigen List:
Pages A1 to A26:
339 Entries, 2007 Edition of Kuby
How to Understand CD Antigens:
5 Persons in a Room
Person 1:
Person 2:
Person 3:
Person 4:
Person 5:
5 ft 5”, 160 lbs bespectacled old geezer
5 ft 11”, 280 lbs, 22-year old guy, all muscle
5 ft 5”, 135 lbs, 20-year-old woman
7 ft 1” , 200 lbs, 22 year-old guy
5 ft 8”, 150 lbs, 22 year-old guy
Person 1:
Person 2:
Person 3:
Person 4:
Person 5:
5 ft 5”, 160 lbs bespectacled old geezer
5 ft 11”, 280 lbs, 22-year old guy, all muscle
5 ft 5”, 135 lbs, 20-year-old woman
7 ft 1” , 200 lbs, 22 year-old guy
5 ft 8”, 150 lbs, 22 year-old guy
This is a fill-in-the-blank question. Please enter your responses
as a series of numbers from 1 to 5.
Which Person:
A. Is a varsity basketball player?
B. Plays on the women’s field-hockey team?
C. Is a boring old professor?
D. Is a varsity football player for SU?
E. Is a cross-country runner?
__ __ __ __ __
Secrets of Signaling
1. How Do You Knock on a Door?
2. Why does the phone “ring” more than once?
3. Why can the police officer directing traffic blow his whistle only
once?
4. Why does your computer say “Are You Sure You Want to Delete
File XYZ?”
5. When the class was directed to do “Bunny Ears” behind the person
next to them, only a few persons responded. Why was that?
6. A different set of persons responded when asked to raise their right
hand. Why was that?
Secrets of Signaling (2)
7. Only the guys in the front of the room responded when I invited
the class to do what all classes would love to do to a pain-in-the next
Prof. Why was that?
8. I asked the class to raise both hands but no one complied. Why is
that?
Signal, Receptors, and co-receptor Pairs
Costimulatory signals: B7 –
CD28
Costimulatory Signals: T-Cell to
MPh
Cancer Eluding Costimulatory
Signal
CD’s on B, T, and NK Cells
(“ALL” = Acute Lymphocytic
Leukemia)
T-Cell ALL Markers
Kuby, 5th Edition
p. 157
Pre-B-Cell ALL Markers
(“ALL” = Acute Lymphocytic
Leukemia)
Kuby, 5th Edition
p. 157
(“CLL” = Chronic
Lymphocytic Leukemia)
B-Cell CLL Markers
Kuby, 5th Edition
p. 157
Leukocyte Recirculation
Lymphocyte Recirculation
Leucocytes in Capillaries
Cartoon
Leucocytes in Capillaries Photo
Extravasation of Naïve T-Cell into Lymph Node
Adhesion: Leucocytes to
Endothelium
(Non-inflamed Endothelium)
CAM = Cell Adhesion
Molecules
Membrane of Circulating
Leucocytes
General Structures of
Cell Adhesion Molecules (CAMs)
Kuby, 3rd Edition
Figure 15-2a
CAMStruct
Endothelial Cells
Lining Capillaries
(Inflamed Endothelium)
CAMinCap Adhesion in
Capilaries
Animations
Produced for Kuby Immunology
OnLine Link
http://bcs.whfreeman.com/immunology6e/
In Class Use Book CD:
Chapter 2: Cells of the Immune-system (Static)
Cell Death : (Animated)
Chapter 11: Signal Transduction (Animated)
Chapter 4 : Immunoglobulins (Static)
Chapter 13 Animation. Leukocyte Extravasation (Animated)
Please put away all notes and any devices except
for your Turning Point NXT Transmitter.
No papers or computers on your desk please.
No communication between or among students.
Animations
Produced for Kuby Immunology
http://bcs.whfreeman.com/immunology6e/
Or search “Kuby Immunology”,
Click on “Kuby Immunology 6e” ,
go to Student Resources
Chapter 2: Cells
Cell Death (Also chapter 10)
Chapter 11: Signal Transduction
Chapter 13: Leucocyte Extravasation
Actin Cytoskeleton Linkage to Collagen
Extra-cellular Matrix
Figure 19-14 ECB
1998, p. 603
Collagen
Fibronectin
Integrin
Plasma Membrane
Actin Microfilament
MFtoECM
Tissue-target Cells in Red
Leucocyte CAM in Blue
CAMFamly
On Endothelial
Cells
On Neutrophils
On Mucosal Epithelium
On Leucocytes
On Endothelial
Cells
On Leucocytes
CamFamly
On Endothelial
Cells
Families of
Cell Adhesion
Molecules
Kuby, 3rd Ed.
Figure 15-2b