Transcript Tissues and Organs Comprising the Immune Response System

Tissues and Organs
Comprising the Immune
Response System
Where components of the immune response
originate,
differentiate,
meet,
interact,
and function
Folder Title: Tiss&Org
Updated: November 10, 2015
APC and T-Cells
Marcophage and T-Cell Kissing
Macrophage to T-Cell Interaction
Helper T-cell B-Cell Interaction
CD4 co-receptor
B-Cell Activation
See figure 2-7,
Kuby, 4th Ed.,
p. 36
B-Cell: Small, Blast, and Plasma
See Figure 2-7,
Kuby 4th Ed.
p. 36
Where do these cells originate?
Where do they go to interact with each other?
Where do they carry out their functions?
Related to Figure
2-13, Kuby, 4th
Edition, p. 47
Primary and Secondary
Lymphoid
Animations
Produced for Kuby Immunology
Online Link
http://bcs.whfreeman.com/immunology6e/
(In Class Do animations from the Book CD)
Chapter 2 Animation. Cells and Organs
Please put away all notes and any devices except
for your Turning Point NXT Transmitter.
No papers or computers on your desk please.
No communication between or among students.
Exactly* what kind of Cell is the one attached to the B-Cell?
*(“exactly” means not just its general type of cell, but
specifically what type of cell it is based on what this figure
shows that the cell is doing)
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What is the blue thing that looks like an alligator clip on
the cell attached to the macrophage or to the B-cell?
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What is the purple thing that looks like a hook on the cell
attached to the macrophage or to the B-cell?
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Purple
Thing
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Thymus Photo
Thymus Cartoon
Diagrammatic Cross Section of Thymus. Figure 2-14,
Kuby, 4th Edition, p. 48
ThymusCross
CD4 and CD8 in Thymus
MALT and M-Cells
See Figure 2-22,
Kuby 4th Ed.
p. 56
MALT and IgA
See Figure 2-22
Kuby, 4th Ed.
p. 56
CD Antigen Table
CDMarks
CD Antigens Color Coded
Animations
Produced for Kuby Immunology
http://bcs.whfreeman.com/immunology6e/
Chapter 11 Animation. Signal Transduction
CD Antigen List:
Pages A1 to A26:
339 Entries, 2007 Edition of Kuby
How to Understand CD Antigens:
5 Persons at a University
Person 1:
Person 2:
Person 3:
Person 4:
Person 5:
5 ft 5”, 160 lbs bespectacled old geezer
5 ft 11”, 280 lbs, 22-year old guy, all muscle
5 ft 5”, 135 lbs, 20-year-old woman
7 ft 1” , 200 lbs, 22 year-old guy
5 ft 8”, 150 lbs, 22 year-old guy
Person 1:
Person 2:
Person 3:
Person 4:
Person 5:
5 ft 5”, 160 lbs bespectacled old geezer
5 ft 11”, 280 lbs, 22-year old guy, all muscle
5 ft 5”, 135 lbs, 20-year-old woman
7 ft 1” , 200 lbs, 22 year-old guy
5 ft 8”, 150 lbs, 22 year-old guy
Which Person:
A. Is a varsity basketball player?
B. Plays on the women’s field-hockey team?
C. Is a boring old professor?
D. Is a varsity football player for SU?
E. Is a men’s cross-country runner?
1C; 2D; 3B; 4A; 5E
Signal, Receptors, and co-receptor Pairs
Secrets of Signaling
1. How Do You Knock on a Door? Why that way?
2. Why does the phone “ring” more than once?
3. Why can the police officer directing traffic blow his whistle only
once?
4. Why does your computer say “Are You Sure You Want to Delete
File XYZ?”
5. When the class was directed to do “Bunny Ears” behind the person
next to them, only a few persons responded. Why was that?
6. A different set of persons responded when asked to raise their right
hand. Why was that?
7. No one responded when the class was asked to stand up. Why?
Secrets of Signaling (2)
8. Only the guys in the front of the room responded when I invited
the class to do what all classes would love to do to a pain-in-the neck
Prof. Why was that?
9. I asked the class in plain English to raise both hands but no one
complied. Why is that? What did that illustrate about properties of
signaling.
10. I gave the answer to the coming quiz question to the entire class
in plain English but no one heard the answer even though I said it
clearly and loudly. Why not? What did that illustrate about cell
signaling?
11. Why does the T-Helper Cell physically attach itself to the
macrophage? What is the advantage of that?
Costimulatory signals: B7 –
CD28
To Here: Nov. 4, 2014; 2nd Exam Nov. 6th
Costimulatory Signals: T-Cell to
MPh
Cancer Eluding Costimulatory
Signal
CD’s on B, T, and NK Cells
Surface
Determinants on
B-Cells:
Immunoglobulins
B7
Surface Determinants
on T-Lymphocytes:
Note: CD4 TH
CD8 TC
CD28 and CD3 Both.
NK Determinants:
CD56
CD16
CD8
CD Markers in Leukemia
Diagnosis
Staging
Prognosis
Treatment
(“ALL” = Acute Lymphocytic
Leukemia)
T-Cell ALL Markers
Kuby, 5th Edition
p. 157
Pre-B-Cell ALL Markers
(“ALL” = Acute Lymphocytic
Leukemia)
Kuby, 5th Edition
p. 157
(“CLL” = Chronic
Lymphocytic Leukemia)
B-Cell CLL Markers
Kuby, 5th Edition
p. 157
Leukocyte Recirculation
How Do Circulating Hematopoietic
Cells “Know” Where They Are?
How Do they Stick?
How Do they Move?
Lymphocyte Recirculation
Leucocytes in Capillaries
Cartoon
Leucocytes in Capillaries Photo
Extravasation (Getting out of the Blood Stream)
of Naïve T-Cell into Lymph Node
CAM =
Cell Adhesion Molecule
Adhesion: Leucocytes to
Endothelium
(Non-inflamed Endothelium)
CAM = Cell Adhesion
Molecules
Membrane of Circulating
Leucocytes
General Structures of
Cell Adhesion Molecules (CAMs)
Kuby, 3rd Edition
Figure 15-2a
CAMStruct
Endothelial Cells
Lining Capillaries
CAMinCap Adhesion in
Capilaries
(Inflamed Endothelium)
Neutrophils trails guide virus-specific CD8+ T cell migration.
Chemokine from
Uropod of
Neutrophils
Kihong Lim et al. Science 2015;349:aaa4352
Published by AAAS
Neutrophils trails guide virus-specific CD8+ T cell migration.
(CXCL12 is a chemokine: chemical agent attracting cell movement)
Virus-specific Cytotoxic T-Cell
Blebs containing CXCL12 from Uropod
(Trailing membrane region) of Neutrophil
“Bread-crumb” trail
Kihong Lim et al. Science 2015;349:aaa4352
Cytotoxic T-Cell migration through trachea to virus-infected cells
Published by AAAS
Please put away all notes and any devices except
for your Turning Point NXT Transmitter.
No papers or computers on your desk please.
No communication between or among students.
When a leukocyte traveling in the blood-stream enter the capillary
circulation in a tissue that is under bacterial attack, which of the following
happen? The system should accept four correct answers
1.
2.
3.
4.
5.
6.
7.
8.
The leucocyte immediately degranulates
The leukocyte goes into cell division
The leukocycte binds to the capillary
endothelial cells (High endothelial venules)
The leukocyte rolls along the endothelial
lining.
The leukocyte elicits membrane signals from
the endothelial cells that bind the leukocyte
tightly.
The endothelial cells then enter apoptosis
The leukocyte extravastates
The leukocyte makes antibodies
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Which of the following are Primary Lymphoid Organs?
(Two responses should be accepted by the system)
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Mucosal associated lymphoid
tissue (MALT)
Tonsils
Adenoids
Thymus
Thyroid
Bone marrow
Cervical lymph nodes
Spleen
Lumbar lymph nodes
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If a red blood cell is an
erythrocyte, what is a T-cell?
_________________ cyte
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Slides Beyond this Point Not included in
BIO447, Fall, 2014
On a scale from –2 to +2
(Use #1 on Key-pad) -2 = I’m lost;
5
(Use #2 on Key-pad) -1 = I’m having a hard time, but I follow some of it.
(Use #3 on Key-pad) 0 = I’m doing OK. I uderstand most of it.
I can figure the rest out later.
(Use #4 on Key-pad) +1 = I’m following OK. No problem
(Use #5 on Key-Pad) +2 = This is pretty straight-forward, Please move on.
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Duration: 0 Seconds
How Well Are You Following What is Being Presented so
Far in theCourse?
(This will be set to anonymous so you will not be identified
and your response will not be graded)
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I’m totally lost.
I’m having hard time, but I follow some of it.
I’m OK. I can figure most of it out later.
I’m following very well. There is no problem with the
level of the course.
This isn’t pitched at a level appropriate for an upper
division undergraduate course. Please move to a
higher level of challenge.
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Animations
Produced for Kuby Immunology
http://bcs.whfreeman.com/immunology6e/
Or search “Kuby Immunology”,
Click on “Kuby Immunology 6e” ,
go to Student Resources
Chapter 2: Cells
Cell Death (Also chapter 10)
Chapter 11: Signal Transduction
Chapter 13: Leucocyte Extravasation
Actin Cytoskeleton Linkage to Collagen
Extra-cellular Matrix
Figure 19-14 ECB
1998, p. 603
Collagen
Fibronectin
Integrin
Plasma Membrane
Actin Microfilament
MFtoECM
Tissue-target Cells in Red
Leucocyte CAM in Blue
CAMFamly
On Endothelial
Cells
On Neutrophils
On Mucosal Epithelium
On Leucocytes
On Endothelial
Cells
On Leucocytes
CamFamly
On Endothelial
Cells
Families of
Cell Adhesion
Molecules
Kuby, 3rd Ed.
Figure 15-2b
Animations
Produced for Kuby Immunology
OnLine Link
http://bcs.whfreeman.com/immunology6e/
In Class Use Book CD:
Chapter 2: Cells of the Immune-system (Static)
Cell Death : (Animated)
Chapter 11: Signal Transduction (Animated)
Chapter 4 : Immunoglobulins (Static)
Chapter 13 Animation. Leukocyte Extravasation (Animated)
T-Cells are lymphocytes that are “educated”
in the
1. Tonsils
2. Toe-nails
3. Teeth
4. Thyroid
5. Thymus
6. Testicles
7. Thoracic Duct
8. None of the above
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