Transcript The Cell Cycle

The Cell Cycle
Year 12 Biology C9
Draw a circle to the
left hand side of the
page
Divide the circle
into four sections
Divide the righthand quarter into
fourths.
G2 Phase
Label the quarters
M
P
h
a
s
e
S Phase
G1 Phase
G2 Phase
Label the phases of
M-phase (Mitosis)
M
P
h
a
s
e
S Phase
G1 Phase
Add details of each
phase of mitosis.
G2 Phase
S Phase
G1 Phase
Add details of each
phase of mitosis.
G2 Phase
S Phase
G1 Phase
Add details of each
phase of mitosis.
G2 Phase
S Phase
G1 Phase
Add details of each
phase of mitosis.
G2 Phase
S Phase
G1 Phase
Add details of each
phase of the cell
cycle
G2 Phase
S Phase
G1 Phase
Add details of each
phase of the cell
cycle
G2 Phase
S Phase
Cell growth
Energy
Organelles
G1 Phase
Add details of each
phase of the cell
cycle
G2 Phase
S Phase
DNA
Synthesis
Cell growth
Energy
Organelles
G1 Phase
Add details of each
phase of the cell
cycle
G2 Phase
Cell Growth
Energy
S Phase
DNA
Synthesis
Cell growth
Energy
Organelles
G1 Phase
Add checkpoints
G2 Phase
Cell Growth
Energy
S Phase
DNA
Synthesis
Cell growth
Energy
Organelles
Check for
DNA Damage
Cell big
enough?
G1 Phase
Add checkpoints
G2 Phase
Cell Growth
Energy
S Phase
DNA
Synthesis
Cell growth
Energy
Organelles
Check for
DNA Damage
Cell big
enough?
G1 Phase
Check for DNA
Synthesis
Cell size
Add checkpoints
G2 Phase
Cell Growth
Energy
S Phase
DNA
Synthesis
Cell growth
Energy
Organelles
Check for
DNA Damage
Cell big
enough?
G1 Phase
Check for DNA
Synthesis
Cell size
Add checkpoints
G2 Phase
Cell Growth
Check for DNA
Synthesis
Cell size
Energy
S Phase
Hold to break
down cyclins
DNA
Synthesis
Cell growth
Energy
Organelles
Check for
DNA Damage
Cell big
enough?
G1 Phase
Add checkpoints
G2 Phase
Cell Growth
Check for DNA
Synthesis
Cell size
Energy
S Phase
Pause to break
down cyclins
DNA
Synthesis
Cell growth
Energy
Organelles
Check for
DNA Damage
Cell big
enough?
G1 Phase
Add checkpoints
G2 Phase
Cell Growth
Check for DNA
Synthesis
Cell size
Energy
S Phase
Pause to break
down cyclins
DNA
Synthesis
Cell growth
Energy
Organelles
Check for
DNA Damage
Cell big
enough?
G1 Phase
Add external
growth factors…
G2 Phase
Cell Growth
Energy
S Phase
DNA
Synthesis
Cell growth
Energy
Organelles
G1 Phase
Nucleus
Mitosis promoting
factor (e.g. hormone)
Nucleus makes
internal regulators..
G2 Phase
Cell Growth
Energy
S Phase
DNA
Synthesis
Cell growth
Energy
Mitosis promoting
factor (e.g. hormone)
Organelles
Nucleus
G1 Phase
Kinase
Cyclin
Nucleus makes
internal regulators..
G2 Phase
Cell Growth
Energy
S Phase
DNA
Synthesis
Cell growth
Energy
Organelles
G1 Phase
Nucleus
CDK complex
Mitosis promoting
factor (e.g. hormone)
CDKs build up…
G2 Phase
Cell Growth
Energy
S Phase
DNA
Synthesis
Cell growth
Energy
Organelles
G1 Phase
CDK complex
CDKs build up…
G2 Phase
Cell Growth
Energy
S Phase
DNA
Synthesis
Cell growth
Energy
Organelles
G1 Phase
CDK complex
CDKs build up…
G2 Phase
Cell Growth
Energy
S Phase
DNA
Synthesis
Cell growth
Energy
Organelles
G1 Phase
CDK complex
CDKs build up…
G2 Phase
Cell Growth
Energy
S Phase
DNA
Synthesis
Cell growth
Energy
Organelles
G1 Phase
CDK complex
CDKs build up…
G2 Phase
Cell Growth
Energy
S Phase
DNA
Synthesis
Cell growth
Energy
Organelles
G1 Phase
CDK complex
G2 Phase
Cell Growth
Energy
S Phase
CDKs start to break
down…
DNA
Synthesis
Cell growth
Energy
Organelles
G1 Phase
CDK complex
G2 Phase
Cell Growth
Energy
S Phase
CDKs start to break
down…
DNA
Synthesis
Cell growth
Energy
Organelles
G1 Phase
CDK complex
G2 Phase
Cell Growth
Energy
S Phase
DNA
Synthesis
Cell growth
Energy
Organelles
G1 Phase
Only when all CDK
has broken down
can the cell proceed
to Metaphase…
G2 Phase
Cell Growth
Energy
S Phase
DNA
Synthesis
Cell growth
Energy
Organelles
G1 Phase
Only when all CDK
has broken down
can the cell proceed
to Metaphase…
G2 Phase
Cell Growth
Energy
S Phase
DNA
Synthesis
Cell growth
Energy
At telophase the
cell can go into G0
phase (and remain
there) or continue
on to the cell
cycle…
Organelles
G0 phase
G1 Phase
G2 Phase
Cell Growth
Energy
S Phase
DNA
Synthesis
Cell growth
Energy
The cell may then
become
differentiated into
any one of the 200
body cells in
humans..
Organelles
G0 phase
G1 Phase
Differentiation
G2 Phase
Cell Growth
Energy
S Phase
Role of inhibitors…
•p27blocks the
build up of CDK
complex during G1
and prevents
movement to S
phase
DNA
Synthesis
Cell growth
Energy
Organelles
G1 Phase
p27
CDK complex
p53
G2 Phase
Cell Growth
Energy
p53
S Phase
Role of inhibitors…
•p27blocks the
build up of CDK
complex during G1
and prevents
movement to S
phase
•p53 stops cell cycle
at any point if DNA
is damaged.
DNA
Synthesis
Cell growth
Energy
Organelles
G1 Phase
p53
CDK complex
G2 Phase
Cell Growth
Energy
S Phase
Role of inhibitors…
If mutations occur
to inhibitors –
cancer may result
i.e. uncontrolled
cell cycle.
DNA
Synthesis
Cell growth
Energy
Organelles
G1 Phase
CDK complex