Transcript Document

K-RITH Seminar
Guest Speaker: Valerie Mizrahi
Director: Institute of Infectious Disease and Molecular Medicine (IDM) and
Molecular Mycobacteriology Research Unit, University of Cape Town
Friday 26 June
12 pm
K1 Seminar Room, K-RITH Tower Building
Targeting core metabolic pathways
a
in
M. tuberculosis
ABSTRACT
Research in my laboratory is aimed at identifying metabolic vulnerabilities in
M. tuberculosis and elucidating mechanisms by which the inhibition of core
metabolic functions results in death of the tubercle bacillus. In this talk, I
will describe the integrated genetic, biochemical and physiological approach we
are taking to address these questions using pyrimidine metabolism and coenzyme A
metabolism as illustrative examples