Transcript micman

MICROBES AND MAN
Research Programme 2003-2005
MICMAN Final Symposium 2006
MICMAN
• Implemented jointly by the Academy of Finland (AF)
and
the Swedish Foundation for Strategic Research (SSF)
• Budget: 5,4 million €
• 15 projects (26 research groups)
Finland: 4.1 M€
Sweden: 1.3 M€
Finland: 21 groups
Sweden: 5 groups
MICMAN Final Symposium 2006
OBJECTIVES
• to increase our knowledge of the interaction between
host and microbes
• to apply this knowledge to the maintenance of health and
the prevention and treatment of diseases
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to generate multidisciplinary networks
to promote researcher training and exchange
to promote international contacts
to strengthen cooperation between universities and research
institutes
MICMAN Final Symposium 2006
BEFORE
Pre-MICMAN planning
2001-2002
MICMAN
MICMAN Final Symposium 2006
INITIATIVE FOR MICMAN
• Exploratory workshop
Microbes and Man - Health, Nutrition and Environment
August 2001 in Gustavelund (near Helsinki)
– 140 researchers,
– Chair: Res.prof. Pentti Huovinen, KTL
–
Topics for the programme
MICMAN Final Symposium 2006
Milestones of preparation
Aug 2001
Exploratory workshop
Nov 2001
Decision on the programme by the Academy
Dec 2001
Negotiations between funding organisations
Feb-Mar 2002 Programme memorandum
April 2002
Launch of the programme
May 2002
Deadline: Plans of intent
June 2002
Decisions: Plans of intent
Sep 2002
Deadline: Applications proper
Nov 2002
Evaluation
Dec 2002
Decisions on accepted projects
Jan 2003
The projects start
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MICMAN proposals
96
PLAN OF
INTENT
28
FULL
APPLICATIONS
15
FUNDED
PROJECTS
MICMAN Final Symposium 2006
21 Finnish groups
5 Swedish groups
The steering programme committee
2002-2003
2004-2006
Academy of Finland:
Prof Marja Makarow, (UH) (chair)
Prof Timo Vesikari, (UTa)
Prof Annele Hatakka, (UH)
Prof Juha Sihvola, (UJy)
Prof Marja-Liisa Hänninen, (UH)
Res.Prof Tiina Mattila-Sandholm (Valio)
Swedish Foundation for Strategic Research:
Dr. Henryk Wos
Prof Olle Stendahl, Lindköping University
Prof Hans Wolf-Watz, Umeå University
Dr. Olle Edqvist
An additional expert:
Academician, prof Pirjo Mäkelä, KTL
Also participating from the Academy of
Finland:
Dr. Soile Juuti
Dr. Sirpa Nuotio
Dr. Tuula Aarnio
MICMAN Final Symposium 2006
DURING THE PROGRAMME
MICMAN projects
2003-2005
MICMAN
MICMAN Final Symposium 2006
MICMAN THEMES
15 PROJECTS:
Other
5 Finnish-Swedish consortia
2 Finnish consortia
8 Finnish individual projects
- bioinformatics;
environmental microbes
2
4
9
Resident microbiota
- influence of internal and
external factors
(host itself, pathogenic and
probiotic bacteria)
Host-microbe interactions
in the development and course of
diseases
MICMAN Final Symposium 2006
15 MICMAN PROJECTS
Consortium: Bacterial-epithelial
cross-talk and the establishment
of the mucosal immune system
Consortium: Microbial factors and
host responses discriminating
commensals from pathogens
Pathogenesis of reactive arthritis:
Research of abnormal hostmicrobe interaction
Consortium: A paradox of a
microbe and man - what makes
Staphylococcus aureus a
pathogen?
Consortium: Microbial ecology of
man in health and disease: Emergence, spread and persistence of
Antibiotic resistance in the normal
Microflora (ESPAR)
Consortium: Host-microbe
interaction in acute and persistent
Chlamydia pneumoniae infection
Microbes and allergy: From
population observations to animal
models and prevention products
Microbial pathogenesis of
cardiovascular disease
Host-microbe crosstalk in infancy:
creating a balance between the
internal and external environments
Consortium: Genetic susceptibility
to streptococcal infections
DNA microarrays for studying
interactions of probiotic,
pathogenic and normal gut
microbiota bacteria with human
intestinal epithelial cells
Consortium: Reactivation and
immune evasion of Borrelia
infection
Microbial resistance to innate
immunity
Cyanobacteria and adjacent
microbes: causes of acute human
intoxications and indicators of
water quality
Infectious origins of the human
genome. Human endogenous
retroviruses in health and disease
MICMAN Final Symposium 2006
MICMAN Coordination
To advance the objectives of the programme
• Communication
– www-pages, MICMAN News, seminars/symposia/meetings,
publicity relations
• Administrative tasks
– Planning, lauching, proposal evaluations, annual reports,
final evaluation
• Researcher training
– Graduate school proposals (InfBio) (under evaluation)
• International contacts to other programmes
– ERA-NET PathoGenoMics (2004-2009)
• Programme manager:
Soile Juuti, National Public Health Institute
Contact person at the SSF: Scientific secretary Henryk Wos
MICMAN Final Symposium 2006
MICMAN EVENTS
Talks
Particip.
(n)
30.1.2003 MICMAN Opening Symposium
13
58
11-12.2.2004 MICMAN Annual Symposium 2004
16
92
16-17.2.2005 MICMAN Annual Symposium 2005
15
83
14-15.3.2006 MICMAN Final Symposium 2006
14
97
Prof. Volkmar Braun and prof. Pirjo Mäkelä
MICMAN Final Symposium 2006
2005
Prof. Seppo Meri
MICMAN Final Symposium 2006
MICMAN EVENTS
Talks
Particip.
(n)
18.9.2003 1st Finnish Microbial Pathogenesis Day
20
125
7.10.2004 2nd Finnish Microbial Pathogenesis Day
10
74
5.10.2005 3rd Finnish Microbial Pathogenesis Day
8
84
Sept. 2006 4th Finnish Microbial Pathogenesis Day
“The aim of these seminars is to invite researchers on microbial pathogenesis together
and advance scientific discussion between the research groups.”
With prof. Mikael Skurnik, Univ. Helsinki
MICMAN Final Symposium 2006
MICMAN Consortia events
Open seminars:
Talks
Particip.
(n)
3.6.2004 Chlamydia pneumoniae research in
Finland: Update and future plans
17
47
20.10.2005 Infection, Inflammation and
Atherosclerosis
13
70
With prof. Pekka Saikku, Univ. Oulu
res.prof. Maija Leinonen, KTL
doc. Mirja Puolakkainen, KTL
MICMAN Final Symposium 2006
MICMAN Consortia events
Closed seminars:
Talks
Particip.
(n)
19-21.4.2004 Reactivation and immune evasion 15
of Borrelia infection
18
20-22.5.2005
27
12
With prof. Sven Bergström, Univ.Umeå
prof. Matti Viljanen, Univ.Turku
+ prof. Seppo Meri, Univ. Helsinki
MICMAN Final Symposium 2006
2005
MICMAN Final Symposium 2006
MICMAN Consortia events
CLOSED SEMINARS:
Talks
Particip.
(n)
22-23.8.2003 Bacterial-epithelial cross-talk and the 10
establishment of the mucosal immune system
10
31.8.-1.9.2005
13
13
With prof. William Agace, Univ.Lund
prof. Mikael Skurnik, Univ.Helsinki
prof. Sirpa Jalkanen, Univ. Turku
MICMAN Final Symposium 2006
MICMAN Consortia events
- Regular meetings of the consortium
Microbial ecology of man in health and disease:
Emergence, spread and
persistence of antibiotic
resistance in the normal
microflora (ESPAR)
Prof. Charlotta Edlund
Karolinska Inst. and
Res.prof. Pentti Huovinen
KTL
- Meetings of other
consortia
MICMAN Final Symposium 2006
MICMAN travel support
Support to doctoral students for short-term visits, 6800 €
MICMAN
Finland
Sweden
MICMAN Final Symposium 2006
Other
• Graduate School in Infection Biology (2007-2011)
– Proposal submitted Dec. 2005
– 32 groups from the Universities of Helsinki, Turku and Oulu
and the National Public Health Institute
– Decision ~May 2006
• ERA-NET PathoGenoMics
– EU 6thFP project between funding agencies
– MICMAN/Academy of Finland as a partner
– European research programme on Pathogenomics
2007-2009: Deadline of proposals to the call by 31.3.2006
– Funding allocated by the Academy ~1,5 Million €
MICMAN Final Symposium 2006
www.aka.fi/micman
MICMAN Final Symposium 2006
AFTER
MICMAN evaluation
2006
MICMAN
MICMAN Final Symposium 2006
REPORTING
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Final report
AF: The final report of the AF using electronic services
SSF: The final report form used by the SSF at
www.aka.fi/micman <results
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Self-Evaluation report
An abstract, facts and thoughts of the programme
Deadline 31.3.2006
MICMAN Final Symposium 2006
EVALUATION
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International evaluation panel:
Prof.
Prof.
Prof.
Prof.
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Guy Cornelis, University of Basel, Swizerland (chair)
Robert Sim, MRC Immunochemistry Unit, Oxford, UK
Ann-Mari Svennerholm, University of Gothenburg, Sweden
Gunna Christiansen, Aarhus University, Denmark
Based on
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E.g. Self-evaluations, final reports, interviews,
additional summary material
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Panel meeting 17-18.10.2006 in Helsinki
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Evaluation report written by the panel
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Concerns all project groups and coordination
MICMAN Final Symposium 2006
EXPERIENCES
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Commitment of the researchers to the programme
Active participation of the graduate students!
Strengthning the Finnish-Swedish collaboration
in research
Collaboration between the FIN-SWE funding
agencies was successful
Heritage of MICMAN:
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Graduate school in Infection Biology
ERA-NET PathoGenoMics (?)
???
MICMAN Final Symposium 2006
MICMAN Final Symposium 2006