Transcript ncn-talk-clinical-barry-smith-the-symprove-story-2014-10

SYMPROVE
The Probiotic Market
The probiotic market is worth $32
billion globally
60% of UK/Irish households
regularly purchase them
A wide variety of probiotics on the
market that claim to work
So, do they work?
Do they contain the claimed
number of viable organisms
stated on the label?
Scientists at University College
Do
they possess
the
London
(UCL) independently
robustness
transit
through
conducted atostudy
that
compared
the
gut? probiotic brands to find
leading
out the truth.
 Aim: To subject the products to three
challenge tests to assess if the bacteria:
ARRIVED
In a live state
SURVIVED
Stomach acid transit
THRIVED
In the target area of the gut
4
ARRIVED
Only dairy-based (Actimel, Yakult) or waterbased (Symprove) probiotics delivered
100% or more than the claimed content
Arrived
Delivers at least 75%
of the amount claimed
for the product
Symprove
Yakult
Actimel
5
SURVIVED
Only two products survived stomach transit
time (120 minutes), with one of these
continuing to decline.
nly one product seems stable
Survived
After exposure, are the
surviving bacteria still
concentrated enough?
Symprove
VSL#3
Symprove survivability
A real time measurement of the heat (growth) signature of the bacteria colony.
Independent research at University College London (preliminary research – not yet published)
100
0
Faster and stronger
growth than all others
Even stronger if acid
attrition in the stomach
is considered
Key:
Symprove
Dairy
Dairy
Dry
Big Brand Dry
Dry
600
P (µW)
The only product to
grow in a realistic time
to give benefit
800
400
200
0
0
20
40
60
TIME (h)
80
100
120
Symprove survivability post pH shock
A real time measurement of the heat (growth) signature of the bacteria colony
after exposure to gastric juices.
Independent research at University College London (preliminary research – not yet published)
1200
Key:
Symprove
Dairy
Dairy
Dry
Big Brand Dry
Dry
P (µW)
100
0
800
600
400
200
0
0
20
40
60
TIME (h)
80
100
120
THRIVED
Only three products showed signs of strong growth
within 10 hours. Others showed very slow, or even no
growth
Thrived
Colony starts growing
strongly within 10
hours to hit the target
areas in the gut
VSL3
Actimel
Symprove
9
Summary
To be successful
probiotic product needs
to beat all three
challenge tests
Safely arrive,
survive stomach
acids, and thrive in
the target area of the
gut
Only one product met
all three challenges with several products
failing all three
challenges
10
Overall results
11
Irritable Bowel Syndrome
1 in 5 households contain
someone with IBS
Despite the high prevalence the
condition is extremely poorly
managed
Sufferers try an average of 5
products each month but
around half are still left battling
the symptoms long-term
+ Probiotic efficacy
A probiotic product not only has to reach the gut, it also has to do
something beneficial once it arrives
There is a rationale for the use of probiotics in reducing IBS
symptoms but rigorous clinical testing has been lacking
The efficacy of Symprove has been confirmed in a randomised,
double-blind, placebo-controlled study by King’s College Hospital
13
+ Study results
Significant improvement was achieved in 4 weeks
Improvement continued through the full 12 weeks
Results show that this multi-strain probiotic is safe, welltolerated and efficacious in improving overall symptom
severity in patients with IBS
14
+ Study results
The significant change in pain score is
important as pain is regarded as the key
measure for patient health
15
+ Study results
Patients report an objectively measurable
improvement in their satisfaction with their
bowel habit (constipation and diarrhoea)
16
INTRODUCING
NEW SYMPROVE
What do we know?
• We know it works – KING’s
• We know how it works – UCL
• We know that 1 bottle doesn’t work
• We know price is a barrier
Symprove New Brand World
 Proudly shows that
Symprove is all about
the gut
 Clearly shows where
it works
 Links to Arrive, Survive
and Thrive
 Works on targeted A-S-T
areas of the gut
 The new packaging is
consumer driven and
supports our science
 While it is keeping its
natural and safety
heritage
19
Symprove 12 week commitment
• The consumer commits
• Symprove commits
• The consumer benefits
through:
a. Great value
b. Encouragement to
compliance
• The retailer benefits from:
a. A higher value sale
b. Repeat visits and sales
c. A higher rate of sale
per customer
d. Increased loyalty
Recent press coverage
Monday, 22 September 2014
Any questions….