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Interactive Web-Based Probiotics Database for Healthcare Professionals
Colleen Conlon BS, BA, MS, Nicole Andreini BS, Ariel Mooney RDH, BS, Rishi Ramraj BS, John G. Thomas MS, Ph.D.
Introduction
Endocrine – 12 Articles
- Diabetes
The World Health Organization reported that 30% of the global - Gestational diabetes
population consumes $87.5 billion worth of pre/probiotics a
year[3,4].
Recent advances in metagenomics have fostered greater clarity
of human microbiota and the use of probiotics into two
interactive/complimentary pathways: bioburden reduction and
Immune – 35 Articles
[3,4]
immune up-regulation/modulation .
- Immune regulation
Problem: Considerable confusion and misunderstanding exists - Allergies
about the value of probiotic therapy, fostered by a plethora of - Allergic Rhinitis
commercial products availability without prescriptions. This - Wound Therapy
has caused a lack of uniformity in the use, regulation, and study
of probiotics[1,2].
Hypothesis: Studies indicate that probiotics are successful in Respiratory – 3 Articles
managing a large range of diseases including infections of the - Cystic Fibrosis
- Ventilator Pneumonia
gastrointestinal, urinary, integumentary, endocrine, and
Common
Cold
immune systems.
Neurological- 1 Article
- Brain activity
Oral - 75 Articles
- Candida albicans
- Dental plaque
- Gingivitis
- Perio pathogens
- Strep. mutans
- Halitosis
Cardiovascular- 25 Articles
- Obesity
- Cholesterol
Figure 1. Treatment of
periodontal inflammation with
probiotic gum.
Conclusion
Gastrointestinal – 110 Articles
- Antibiotic Associated Diarrhea
- Acute Gastritis
- Blastocytis hominis
- Candida Colonization
- Colon Cancer
- Celiac
- Clostridium difficle
- Crohn’s Disease
- Constipation
- Diarrhea
- Helicobacter pylori
- IBS
- Liver Disease
- Neonatal Enterocolitis
- Pouchitis
- Regulation of microflora
Results
Surveys confirmed confusion and limited knowledge of
use, benefits, and availability of probiotics both by
consumer and professional health care providers.
There was a significant reservoir of peer reviewed
published literature, mostly international, that described
Joint Health – 2 Article
the use, mechanism of action, and application of
- Arthritis
probiotics with lack of uniformity.
Greatest dental clinical focus included caries, periodontal
disease, halitosis, and Candida infection, with a growing
application in nurseries and daycare centers.
A computer database was constructed providing educational
materials for both consumer and health providers. The
algorithm-based integrated analysis matched clinical disease,
conditions, strength of evidence, microbes, and probiotics
highlighted by literature and survey reviews. Probiotic
summaries were constructed based on observations in the
literature search.
Breast – 2 Article
- Infectious Mastitis
Methods
A survey was given to dental patients and oral health care
providers over the course of 3 years to construct a baseline
of probiotic knowledge and use in the oral health field. The
most recent survey is on our website “Bac2Health survey”.
Over 300 articles were selected and rated based on the type Skin – 15 Articles
- Eczema
and validity of the research. Each paper was ranked on a
- Atopic dermatitis
“Strength of Article” grading scale based on the type of
study performed, indicating if there was statistical
significance or lack of benefit found. Each paper was then
coded to correlate conditions with microbes and probiotic
product. A grading system of A-F was assigned to each
probiotic and bacterium based on the strength of supporting
research found for each condition.
A website was constructed by Rishi Ramraj, using the
Remind platform.
The “Bac2Health” website was created utilizing the
compiled research to allow users to search for information in
several fields such as probiotic, microbe, disease, and
strength of evidence.
Results (cont.)
In view of CDC’s recent proclamation of the “Post Antibiotic
Era”, probiotics and reconstructive microbiology are
emerging from adjunctive therapy to real time intervention[3].
The emergence of oral metagenomics has catalyzed
awareness of disease management via recreating a balanced
eco-system for “restorative microbiology,” particularly in the
[3,4]
fields of gastroenterology and dentistry .
Our interactive database, remaining current with reviews,
comments, and federal guidelines, was constructed to meet
the obvious void in both the consumer and professional
knowledge emphasized by multiple, international probiotic
surveys.
Probiotics/symbiotic and prebiotics are a growing focus of
molecular research with the development of designer
probiotics and “bacterioreplacement therapy”, focusing more
recently on immune up regulation and modulation[3,4].
We anticipate expansion of probiotic oral health to include
endodontics and chronic wounds, given the shared
pathogenicity via MMP’s, recognizing that “toothless
[3,4]
periodontal pockets” are now considered wounds .
We are actively searching for grant support to build the
Bac2Health site that is integrated with industrial, Biotech,
state, international, and federal opportunities.
References
Female reproduction – 20 Articles
- Bacterial Vaginosis
- Vaginal Health
- Yeast infection
1. Danielle Wolvers, Jean-Michel Antoine, Eveliina Myllyluoma, Juergen Schrezenmeir, Hania Szajewska, and Ger T
Rijkers. “Guidance for Substantiating the Evidence for Beneficial Effects of Probiotics: Prevention and Management of
Infections by Probiotics.” The Journal of Nutrition 140, No. 3 (March 2010): 698S –712S. doi:10.3945/jn.109.113753
2. M.F. Zarco, T.J. Vess, G.S. Ginsburg. “The oral microbiome in health and disease and the potential impact on
personalized dental medicine.” Oral Diseases (2012) 18, 109 –120. doi:10.1111/j.1601-0825.2011.01851.x
3. Harpreet Singh Grover, Shailly Luthra. “'Probiotics – the nano soldiers of oral health.” JIACM 2011; 13(1): 48-54.
4. John G Thomas, Khaled Seifelnasr, “Maximizing Clinical Benefits of Probiotics: Matching Metagenomics, Patient Age
and Microbial Composition.” Oral Health Journal, December 2013.