Transcript Fritz Lipmann and Herman Kalckar

Fritz Lipmann and
Herman Kalckar
By Pierre Yammine and Marisa Diguer
Who are they?
• Herman Moritz Kalckar (1908 -1991)
was a Danish biochemist (Wikipedia,
2010)
• Fritz Albert Lipmann (1899 – 1986) was
a German-American biochemist
(Wikipedia, 2010)
Previous Knowledge
• Krebs Cycle
• How cells produce and use energy
The Experiment – Part 1
• Inhibited the process of glycolysis by adding iodoacetate
to the frog muscles. (NAP, 2010)
The Experiment – Part 2
• By using phosphocreatine, muscle contractions
continued.(NAP, 2010)
The Experiment’s Results
• The breakdown of ATP to ADP and
inorganic phosphate drives muscle
contraction (NAP, 2010)
What does this mean?!
• This shows that ATP can still be produced
when glycolysis is inhibited while using
phosphocreatine as a source of energy.
(NAP, 2010)
• This shows that phosphate can link
catabolism and anabolism (NAP, 2010)
References
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Anonymous. "Biology (fall) Flashcards | Quizlet." Flash Cards, Vocabulary
Memorization, and Study Games | Quizlet. Web. 16 Nov. 2010.
<http://quizlet.com/932953/biology-fall-flash-cards/>.
Nord, Friedrich Franz., and Chester Herman. Werkman. Advances in
Enzymology and Related Subjects. New York: Interscience, 1941. Print.
Golden,, Leah. "The History of the Krebs Cycle | EHow.com." EHow | How
To Do Just About Everything! | How To Videos & Articles. Web. 16 Nov.
2010. <http://www.ehow.com/about_5459616_history-krebscycle.html#ixzz15PsT1Obo>.
Anonymous. "Herman Kalckar." Wikipedia, the Free Encyclopedia. Web. 16
Nov. 2010. <http://en.wikipedia.org/wiki/Herman_Kalckar>.
Anonymous. "Herman Kalckar." Wikipedia, the Free Encyclopedia. Web. 16
Nov. 2010. <http://en.wikipedia.org/wiki/Herman_Kalckar>.
Anonymous. "Herman Moritz Kalckar, March 26, 1908—
May 17, 1991 | By
Eugene P. Kennedy | Biographical Memoirs." The National Academies
Press. Web. 16 Nov. 2010.
<http://www.nap.edu/readingroom.php?book=biomems&page=hkalckar.html
>.