Transcript Jeopardy Abbas 4-7 (double) - updated 5/21/2014

Y
Lincoln
M.H.C.
TLRs
Presenting...
an antigen!
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Most antibodies are
found in the this group
of globulins which are
rd
the 3 fastest
migrating.
What are gamma
globulins?
IgG molecules are
cleaved by this enzyme
to form 2 Fab
fragments and 1 Fc
fragment.
What is papain?
These two antibodies
are the best
complement activators.
What are IgM and IgG?
This heavy chain is
expressed on the surface of
pre-B cells, associated
with surrogate light
chains, and is absent in an
autosomal recessive form
of agammaglobulinemia.
What is the μ heavy
chain?
This is the CDR with
the most variability.
What is CDR3?
He killed Lincoln.
Who is John Wilkes
Booth?
What are the first 6
words of the Gettysburg
Address?
What is ‘Four score and
seven years ago’?
In number order, he was
this president of the US.
What is
th
16
president?
Lincoln belonged to this
political party.
What is the Republican
party?
Lincoln was born in this
state.
What is Kentucky?
This is the name of the
set of MHC alleles
present on each
chromosome.
What is a haplotype?
These two chains make up
MHC class I.
What is an α chain and
β2 microglobulin?
Peptides are transported
into the ER for Class I
loading by this
molecule
What is TAP?
This segment of class II
molecules contain the
binding site for CD4.
What is the β2 segment?
This cytokine is encoded
in the MHC
What is TNF α,
lymphotoxin α or
lymphotoxin β?
This TLR binds LPS.
What is TLR4?
These 4 TLRs are
expressed on
endosomes.
What are
TLRs 3, 7, 8, 9?
This TLR does not signal
through MyD88.
What is TLR3?
Polymorphisms in this
“CARD carrying”
member of the NLRs is
associated with Crohn’s
disease.
What is NOD2?
This enzyme is induced
after ligation of TLRs and
function to reduce oxygen
in reactive oxygen species.
What is NADPH (or
phagocyte) oxidase?
It is an accessory
molecule on this cell
that binds to
CD80/CD86.
What is CD28 on T cells?
Cytokine receptors
signal through this
pathway.
What is Jak/STAT?
In TCR signaling, Lyk
phosphorylates ITAMs
on ζ chains in order to
provide a docking site
for this tyrosine kinase.
What is ZAP-70?
The B cell equivalents of
Lck/ZAP-70 are these.
What are Lyn/Syk?
After IP3 mediated
calcium liberation from
the ER, STIM1 induces
the opening of this
channel to allow calcium
influx into the cell.
What is the CRAC
channel?