Major Histocompatibility complex OR
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Transcript Major Histocompatibility complex OR
Major Histocompatibility
complex
OR
MHC
تفاوت آنتي ژنهاي سازگاري
ساختمانی
ژنی
توزیع سلولی
معرفی نوع پپتید
سلول شناسایی کننده
MHC
The principal function of T cells are :
Defense against intracellular microbes
Activation of other cells(B cells ,Macrophages )
peptide recognition by T and B cells is
different.
B cells recognize soluble as well as cell associated Ags
In contrast ,T cells recognize peptide which is displaying only
by APC in associated with MHC proteins.
MHC
MHC genes are the most polymorphic genes
MHC genes are codominantly expressed in each
individual
There are two main type of MHC:class I & II
The physiologic function of MHC molecules is
presentation of peptides to T cells ,control of
immune responsiveness to all proteins and graft
rejection
MHC-I present cytosolic peptides to T cytotoxic
cells and MHC-II present endocytosed peptides
to Th cells
MHC –I structure
MHC-II structure
T cell receptor and MHC
interaction
Polymorphism of class II
HLA-DPA
HLA-DPB
HLA-DQA
HLA-DQB
HLA-DR
12
88
17
42
>400
POLYMORPHISM OF MHC PROTEINS
DR
1
HLA-A >280
DR >400
HLA-B >500
DQ >50
HLA-C >130
Variability is in the amino acid residues in the peptide binding
site!