Transcript No Slide Title - 312Immunology.org

Y
Oscars 2013
M.H.C.
TLRs
Presenting...
an antigen!
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Most antibodies are
found in the this group
of globulins which are
rd
the 3 fastest
migrating.
What are gamma
globulins?
IgG molecules are
cleaved by this enzyme
to form 2 Fab
fragments and 1 Fc
fragment.
What is papain?
These two antibodies
are the best
complement activators.
What are IgM and IgG?
This heavy chain is
expressed on the surface of
pre-B cells, associated
with surrogate light
chains, and is absent in an
autosomal recessive form
of agammaglobulinemia.
What is the μ heavy
chain?
This is the CDR with
the most variability.
What is CDR3?
This Best Picture
nominee was based on
a fable by Yann Martel
that stars a tiger and a
16 year old boy.
What is The Life of Pi?
This Best Picture
nominee was based on a
novel by Victor Hugo
and stars a reluctant
criminal.
What is Les
Misérables?
This Best Picture
nominee stars the
youngest Best Actress
nominee in history.
What is Beasts of the
Southern Wild?
This 2013 Best Picture
nominee stars “Katniss”
from the Hunger Games
and “Phil” from the
Hangover.
What is Silver Linings
Playbook?
This Best Picture
nominee chronicles the
hunt for Osama Bin
Laden and stars Jessica
Chastain.
What is Zero Dark
Thirty?
This is the name of the
set of MHC alleles
present on each
chromosome.
What is a haplotype?
These two chains make up
MHC class I.
What is an α chain and
β2 microglobulin?
Peptides are transported
into the ER for Class I
loading by this
molecule
What is TAP?
This segment of class II
molecules contain the
binding site for CD4.
What is the β2 segment?
This cytokine is encoded
in the MHC
What is TNF α,
lymphotoxin α or
lymphotoxin β?
This TLR binds LPS.
What is TLR4?
These 4 TLRs are
expressed on
endosomes.
What are
TLRs 3, 7, 8, 9?
This TLR does not signal
through MyD88.
What is TLR3?
Polymorphisms in this
“CARD carrying”
member of the NLRs is
associated with Crohn’s
disease.
What is NOD2?
This enzyme is induced
after ligation of TLRs and
functions to reduce
oxygen in reactive oxygen
species.
What is NADPH (or
phagocyte) oxidase?
It is an accessory
molecule on this cell
that binds to
CD80/CD86.
What is CD28 on T cells?
Cytokine receptors
signal through this
pathway.
What is Jak/STAT?
In TCR signaling, Lyk
phosphorylates ITAMs
on ζ chains in order to
provide a docking site
for this tyrosine kinase.
What is ZAP-70?
The B cell equivalents of
Lck/ZAP-70 are these.
What are Lyn/Syk?
After IP3 mediated
calcium liberation from
the ER, STIM1 induces
the opening of this
channel to allow calcium
influx into the cell.
What is the CRAC
channel?