Transcript Sickle Cell PPT

SICKLE CELL DISEASE
By: Xavier Amaro, Destynee Bodrick, Armaiyah
Phelps, Anayeli Ortiz
BACKGROUND/DESTYNEE
Sickle Cell Disease, also known as
drepanocytosis or sickle cell anemia, is a
genetic disorder. The sickle cell disease
was named sickle cell because the red
blood cells of patients look like sickles.
James Bryan Herrick discovered sickle
cells in 1910 in the United States while he
and his friend, Doctor Ernest Irons, looked
at a patient’s red blood cells under a
microscope. The patient had been
experiencing much pain because his red
blood cells were shaped in a sickle.
Infected sickle
cell allele
TYPE OF GENETIC DISORDER/XAVIER
The type of genetic
disorder of sickle cell disease is a
blood disorder, since it affects
the hemoglobin of red blood
cells, which transports oxygen
from the lungs to the whole
body. The disease is inherited in
an autosomal recessive pattern,
meaning that the children won’t
inherit the disease unless each
parents gives a recessive copy of
a sickle cell gene.
Infected sickle
cell allele
A
a
A
AA
Aa
a
Aa
aa
25% chance of offspring having
sickle cell disease
CHROMOSOME 11/XAVIER
• The sickle cell disease is
carried on the 11th
chromosome. It produces a
different hemoglobin that
causes red blood cells to be
in the shape of a sickle.
SYMPTOMS/ANAYELI
• Sudden Episodes of Extreme Pain -The shape of
the blood cell is a sickle so it can get stuck in small
blood vessels, blocking them. This causes a lack of
oxygen in organs, so the result is pain.
• Dizziness and fatigue- low oxygen in body causes
the body to not function well
• Urinary problems-inability to make concentrated
urine because of little blood in the urine
• Damage to organs and body pieces- low oxygen
causes organs to break down
EFFECTS OF DISORDERS/ARMAIYAH
• Pain- clots of sickle cells can
result in lack of oxygen in the
blood vessel.
• Organ damage- organs get
little to no oxygen, meaning
that organ get damaged
DIAGNOSIS/DESTYNEE
Sickle Cell Disease can be
diagnosed by blood test of the
individual with the disorder.
Once the doctor gets the
blood, he/she will look at the
individual red blood cells. If the
doctor sees a blood cell in a
sickle shape, he/she will
diagnose Sickle Cell Disease.
PROGNOSIS/XAVIER
• In 1973, the average lifespan for
people with sickle cell disease
was only 14 years. Currently, life
expectancy for these patients
can reach 50 years and over.
• The disorder impacts the patient
mentally and physically. Since
the cells block some blood
vessels, it causes constant pain.
Living with a lifetime of pain can
be depressing.
• The disorders affects the family
because the disease causes
lack of oxygen. This makes the
individual be short of breath and
tire easily. This will limit the
persons time outside and with his
family.
TREATMENTS/ANAYELI
Disorder Treatments
• A bone marrow transplant is a
treatment. It includes the
replacing of the infected bone
marrow with healthy, noninfected bone marrow.
After the bone marrow
transplant, it allows the body to
produce healthy, normal red
blood cells.
• Gene therapy was discovered
safe for treating sickle cell
disease by researchers at UCLA.
Symptom Treatments
• Fish oil- fish oil significantly
reduces the frequency of sickle
cell pain
• Folic Acid- treats certain types of
anemia
• Pain Killers- Will reduce the pain
that the patient suffers
CURRENT RESEARCH/ARMAIYAH
Previously, the National
Institutes of Health was looking
into treatments for sickle cell
disease. Treatments were
discovered to be effective to
the disease. As of 2016, there is
no current research.
JAMES E. HAYES/DESTYNEE
As a child my father ached but no one knew why. When he
became a man and medical technology improved, it was
discovered he had sickle cell. I can remember many sleepless
nights watching my father crying and tossing and turning in pain.
He grew up owning his own family business called Poorboys
Supermarket which he ran until his death in 1983. He leaves behind
3 daughters, 3 sons, 11 grandchildren, and 1 great grandson.
-From the words of Ms.Kathy-Hayes
BIBLIOGRAPHY
•
-Chien-Kuang Ding
- Guest Lecture
- Duke University: Genetics Outreach
- Durant Road Middle School
- February 23rd, 2016
•
-Stem Cell Transplant for Sickle Cell Disease
-WebMD
http://www.webmd.com/cancer/bone-marrow-transplant-for-sickle-cell-disease
•
-Sickle Cell Warriors
-Sickle Cell Free, Part 1: An Interview with Patient #19
- http://sicklecellwarriors.com/sickle-cell-free-an-interview-with-patient-19-pt-1/
•
-What Are the Signs and Symptoms of Sickle Cell Disease?
- NHLBI, NI
- http://www.nhlbi.nih.gov/health/health-topics/topics/sca/signs
- UCLA Stem Cell Gene Therapy for Sickle
Cell Disease Advances toward Clinical
Trials - Sickle Cell Foundation of Georgia,
Inc.
- Sickle Cell Foundation of Georgia Inc
- http://sicklecellga.org/ucla-stem-cell-genetherapy-for-sickle-cell-disease-advancestoward-clinical-trials/
•