Transcript Sickle Cell Anemia

Sickle Cell Anemia
By Alex Lange & Roy Darrah
Inheritance Pattern
•Sickle Cell Anemia is a autosomal
reccesive pattern.
• Parents can be
carriers and show
no symptoms of
the disease.
Mutations
• Mutations in the HBB gene causes Sickle
Cell Anemia.
• It consists of four protein subunits, 2
alphaglobins and 2 betaglobins which form a
hemoglobin (C,E,S,AS).
• Hemoglobins bind oxygen in a cell, but amino
acids can switch with betaglobins making the
cell nonfunctional.
Incidences
• Sickle Cell Anemia is most common in people
with African, Mediterranean, and Caribbean
ancestors.
• Sickle Cell Anemia is most common inherited
blood disorder in the US, 70-80 thousand
Americans have this disorder.
• 1 in 500 African Americans and 1 in 1000
Hispanic Americans will have this disorder.
Symptoms
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Shortness of breath
Fatigue
Delayed growth in children
Yellowing of the eyes and skin
Cells can get stuck in veins
Organ damage (lungs, kidneys, spleen,
brain)
• High blood pressure
Treatments
• There is no cure to Sickle Cell Anemia
except for a bone marrow transplant.
Lifetime Limitations
• People can live normal lives
• Others should avoid a lot of physical activity due
to the lack of oxygen and cells
• Stay away from high altitudes
• Ryan Clark plays football for the Steelers and he
has Sickle Cell Anemia. Even though he
struggles with extreme exercises and hypoxia
from high altitudes.