Transcript Sickle cell anemia - abnormally shaped red blood cells that are

Sickle Cell Anemia
Sickle cell anemia - abnormally
shaped red blood cells that are
shaped like a sickle (or crescent).
Hard and sticky, sickle cells don't
move easily through blood
vessels. They get stuck, blocking
blood flow to limbs and organs
causing pain, organ damage, and
a low blood count (anemia).
• Normal red blood cells are smooth and
round like a doughnut without a hole. They
move easily through blood vessels to carry
oxygen to all parts of the body.
The sickle-shaped red blood cells
tend to get stuck in blood
vessels, blocking the flow of
blood.
• Sickle cell anemia is a hereditary disorder
that mostly affects people of African
ancestry, but also occurs in other ethnic
groups, including people who are of
Mediterranean and Middle Eastern
descent.
• Sickle cell anemia occurs when a person
inherits two abnormal genes (one from
each parent) that cause their red blood
cells to change shape.
The map indicates current
distribution of indigenous
malaria according to WHO
Red Cell Defenses Against Malaria
• Membrane
• Duffy antigen null
• Melanesian Elliptocytosis
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Hemoglobin
Hemoglobin S
Hemoglobin C
Hemoglobin E
ß-thalassemia
a-thalassemia
• Red cell enzymes
• G-6-PD deficiency
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