Transcript ageLOC TR90 Science Presentation

Weight Management Gene
Expression Science
Advances in Gene Expression Science
Allow Scientists to Compare & Contrast
Expression Patterns of two Biological States
Biological State #1
Biological State #2 State
Comparison of Genetic Profiles of
Adipose Tissue in Identical Twins
Pietiläinen et al. PLoS Med. 2008 Mar 11;5(3):e51.
Normal Weight Twin
Overweight Twin
Same DNA
Different Expression of Genes
Compared to their normal weight twin, overweight twins exhibited down
regulation of gene expression pathways related to:
•
•
Fat Regulation (storage versus utilization)
Muscle Protein Synthesis
• Deep understanding of gene expression science
• Nu Skin owns patented technologies to study
anti-aging interventions through gene
expression science
Identified Gene Expression Pathways Linked to
Fat Storage and Fat Metabolism
LifeGen pre-clinical study of Adipose, Gastrocnemius muslce, Hypothalamus
Gene Expression relates to the Appetite Control
Center of the Brain
•
•
•
Ghrelin
Leptin
Insulin
Appetite Control
Eating Behavior
Regulation of energy intake
References:
1.
2.
3.
4.
5.
6.
7.
8.
9.
Smeets et al. Proceeding of the Nutrition Society. 2012;71:511-520.
Guthoff M, et al. J Clin Endocrinol Metab. 2010;95:748-755.
De Silva, et al. Cell Metab. 2011;14:700-706.
Malik S, et al. Cell Metab. 2008;7:400-409.
Farooqi IS, et al. Science. 2007;317:1355
Suzuki K, et al. Experimental Diabetes Research. 2012:1-19.
Viquerie N, et al. Diabetologia. 2005;48(1):123-131.
Mager et al. European Journal of Endocrinology. 2008;158:
Mutch DM, et al. Am J Clin Nutr. 2011;94(6):1399-1409.
Formulations Based on:
• Proprietary gene Expression Research
• The latest and most robust nutritional science
Eating Plan Based on:
Protein Science & Nutrition Science
• An eating plan designed to
complement the supplements.
• Supports metabolically-active
lean muscle and inhibits fat
storage1
Reference: Wycherley TP, et al. AJCN. 2012;96(6):1281-98.
Typical Reduced Calorie Diet – 2000 kcal
Fat Storing
Foods
(90g)
(90
g)
Fat Burning
Foods
Proteins
Proteins
Carbohydrates
Carbohydrates
(260g)
(260
g)
(67g)
(67
g)
Fat Storing
Foods
Fats
Fats
Typical Reduced Calorie Diet – 1200
2000 kcal
Fat Storing
Foods
(90g)
(45
g)
Fat Burning
Foods
Proteins
Proteins
Carbohydrates
Carbohydrates
(260g)
(180
g)
(67g)
(33
g)
Fat Storing
Foods
Fats
Fats
Eating Plan – 1200 kcal
Fat Storing
Foods
(90g)
(90
g)
Fat Burning
Foods
Proteins
Proteins
Carbohydrates
Carbohydrates
(260g)
(260
g)
(67g)
(67
g)
Fat Storing
Foods
Fats
Fats
Eating Plan – 1200 kcal
Fat Storing
Foods
(90g)
(90
g)
Fat Burning
Foods
Proteins
Proteins
Carbohydrates
Carbohydrates
(260g)
(120
g)
(67g)
(40
g)
Fat Storing
Foods
Fats
Fats
FAT BURNING
Time in Metabolic Burn Zone = Only 3 hours/day
FAT STORING
ZONES
Eating Most of Your Protein with Only One Meal of the
Day Limits Duration of Metabolic Burn
Breakfast
Lunch
Adapted from:
1. Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86.
2. Layman DL. Nutrition and Metabolism, 2009; 6:12.
Dinner
FAT BURNING
Time in Metabolic Burn Zone = 9 hours/day
FAT STORING
ZONES
Eating Protein with Each Meal
Accelerates Metabolic Burn
Breakfast
Lunch
Adapted from:
1. Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86.
2. Layman DL. Nutrition and Metabolism, 2009; 6:12.
Dinner
Open Label Clinical Study
- 90 Days on ingredients-based program
- 45 women and 21 men completed the study
Participants Reported…
- Lower levels of Hunger
- Changes in body silhouette
- Clothes fit better
- Liked this program better than programs
they had tried previously
Results of unpublished preliminary study 2013
ageLOC TR90 Summary
• Healthy weight management and Body Shaping program.
• Based on gene expression science, addresses key factors
related to weight management:
- Healthy Metabolism,
- Promotes Lean Muscle Maintenance
- Appetite Control
• Studies on TR90 weight management program resulted in
significant weight loss, fat loss and changes in gene
expression.
Nutrition
Science
Gene
Expression
Science
SIGNS & SYMPTOMS
Antioxidant
Science
17
LIFEPAK—THE PERFECT
COMPANION
• Nutritional foundation is important
– LifePak® provides that foundation
• Ensure adequate nutrition during
reduced calorie regimen
• Dietary antioxidants for added
protection from oxidative stress
LifePak Off-sets Oxidative Stress During Dieting
• Participants took LifePak
Average SCS for study
participants
• Scanner Scores increase an average of 6,000 per person
40,000
30,000
36,000
29,000
30,000
Baseline
6 Weeks
20,000
10,000
Data from My Victory Open-label Study 2007
12 Weeks
AGELOC R2 – The Perfect
Companion
• Maintain energy levels
• Assist with cell renewal and
cleansing during lipolysis
TR90 SUPPORT TOOLS
WHAT’S YOUR TRANSFORMATION
NUMBER?
Create and communicate your
personal transformation through a
compelling story and
transformation number that is
completely unique to your ageLOC
TR90 experience.