Transcript Evolution-Part2

Natural Selection
Variation
Natural Selection
Variation
Heredity
Natural Selection
Variation
Heredity
Differential Survival
Fitness Landscape
Sewell Wright
(1899-1988)
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Multi-dimensional spaces
{x,y,z}
Generalize to:
{x,y,z,a,b,c,d,e}
Multi-dimensional spaces
{x,y,z}
Generalize to:
{x,y,z,a,b,c,d,e}
Show K-means model
Fisher’s Fundamental Theorem
Ronald Fisher
(1890-1962)
R. A. Fisher's so-called fundamental theorem of natural selection:
"The rate of increase in fitness of any organism at any time is equal to its genetic variance in fitness at that time."[1]
Or, in more modern terminology:
"The rate of increase in the mean fitness of any organism at any time ascribable to natural selection acting through
changes in gene frequencies is exactly equal to its genetic variance in fitness at that time".[2]
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Information and Matter
Natural history
Evolvability
Modularity: Evo Devo
Evolution of Cooperation/Eusociality
DNA
DNA
Transcription
Translation
Notion of “gene expression”
Epigenetics
From Wikipedia:
“Epigenetics is the study of heritable changes in gene
expression or cellular phenotype caused by mechanisms
other than changes in the underlying DNA sequence.”
http://www.pbs.org/wgbh/nova/body/epigenetics.html
Is epigenetics why cloned animals don’t fare well?
Genetic regulation
Genetic Switches (in “non-expressed” regions)
Lac Operon
http://www.youtube.com/watch?v=oBwtxdI1zvk
Genetic Regulatory Networks
Random Boolean Networks
as models of genetic regulatory networks