Transcript On Bioinformatics

Skin
Ilium
Brain
Muscle
kidney
etc…
A new kind of map
of the human
genome…
The cell cycle
•110 RNA samples from ~9 cycles
•5 independent sychronizations
•Fourier analysis:
~900 periodically-expressed genes
Mike Whitfield
Gavin Sherlock
Orly Alter
Olga Troyanskay
Alok Saldanha
David Botstein
Molecular portraits of
cancer
The genome project’s secret to success…
PUBLISHED DNA SEQUENCES ARE A
FREE PUBLIC RESOURCE!
Freely available for anyone to use for
any research purpose!
'Virus chip' helps yield clue to mystery illness
By Paul Elias The Associated Press
SAN FRANCISCO — It took just a few waves of the computer mouse for Joseph DeRisi to identify the prime
suspect behind the sometimes deadly new mystery illness dubbed severe acute respiratory syndrome (SARS).
ERIC RISBERG / AP Joseph DeRisi, a researcher at the
University of California, San Francisco, holds a slide
containing every known viral sequence at his lab last week.
Viral genome microarray
Novel Coronaviru
ALL
PUBLICATIONS OF PUBLICLY FUNDED
RESEARCH SHOULD BE A PUBLIC
RESOURCE.
Freely available for anyone to use for any
research purpose.
Open Access Working Definition
(HHMI Open Access Workshop - April 2003)
An Open Access Publication is one that meets the following two conditions:
1. The copyright holder(s) grants to the public a free, irrevocable, perpetual right of access to,
and license to copy, distribute, perform, and display the work and to make and distribute
derivative works, in any medium for any purpose.
2. A complete version of the article and all supplemental materials in a suitable standard
electronic format is deposited immediately upon initial publication in at least one internationally
recognized online repository committed to open access, unrestricted distribution and long-term
archiving (example: PubMed Central).
I support
www.PLoS.org
Online public resources in the life sciences:
•Genbank (repository of all published DNA sequences)
•PDB (repository of all published protein structures)
•Stanford Microarray Database (repository of public domain
global gene expression data and software with exploration
tools)
•Pubmed (database of titles and abstracts of life sciences
literature)
•Pubmed central (database of full text and contents of life
sciences literature - sparse)