Transcript L14-421-15-11-18-15 - follow in order to start your

L14-421-15-11-18-15
Music : Amateur / Professional : concentration, learning to listen
• The emergent paradigm & the Peirce model of normativity
• Aesthetic Ethics LogicMetaphysics. What do you think grounds your
ethics? And your metaphysics? If you deploy your metaphysics to limit your
logic, or your ethics to limit aesthetics, you destroy both and cripple yourself.
• Not top down, not propositional: Apposition, assonance: what fits, what
harmonizes
• Not planned, but worked out: qualities that we take a long time to even find that
fit: open exploration to discern consonant relation .
• From Kant to Coleridge to Peirce: not yet in our grasp: a 300 year history of
failures of imagination in building sustainable institutions
• A metaphysical excursus
• The Miller Experiment to Sutherland
• Relational Realism: Epperson and Zafiris
• Law and Symmetry: Bas Van Frassen
• Prigogine and emergent evolution
• The single universe and the reality of time
Miller-Urey experiment, 1952
•
The Miller–Urey experiment[1] (or
Miller experiment)[2] was a chemical
experiment that simulated the
conditions thought at the time to be
present on the early Earth, and tested
the chemical origin of life under those
conditions. The experiment tested
Alexander Oparin's and J. B. S.
Haldane's hypothesis that conditions
on the primitive Earth favoured
chemical reactions that synthesized
more complex organic compounds
from simpler inorganic precursors.
Considered to be the classic
experiment investigating abiogenesis,
it was conducted in 1952[3] by Stanley
Miller, under the supervision of Harold
Urey, at the University of Chicago and
later the University of California, San
Diego and published the following
year. [the vials contained more than
the 20 amino acids essential for life]
Miller-Urey: Wikipedia
"Miller-Urey experiment-en" by GYassineMrabetTalk✉This vector image was created with Inkscape.iThe source code of this SVG is
valid. - Own work from Image:MUexperiment.png.. Licensed under CC BY-SA 3.0 via Commons https://commons.wikimedia.org/wiki/File:Miller-Urey_experiment-en.svg#/media/File:Miller-Urey_experiment-en.svg
John Sutherland U of Manchester
Chemists can plausibly show how each of the three components of
an RNA nucleotide – a base, a sugar, and a phosphate group –
could have formed spontaneously. But the base cannot attach
to the sugar, known as ribose, because the energy of the
reaction is unfavorable.
Researchers have been stuck at this roadblock for 20 years.
Chemists at the University of Manchester, led by John D.
Sutherland, have now provided a way around.
The diagram above shows, in blue, the reaction that doesn't work
and, in green, the new work-around.
Continue reading the main story Related Coverage
Chemist Shows How RNA Can Be the Starting Point for LifeMAY
13, 2009
Both reactions start off with simple chemicals believed to have been
present on the primitive earth. They are glyceraldehyde (10),
cyanimide (8), cyanoacetaldehyde (5) and cyanoacetylene (7).
These chemicals will naturally form the base cytosine (3) and ribose
(4). But the cytosine cannot be made to join to the ribose under
natural conditions.
Working through all possible chemical combinations for 10 years, Dr.
Sutherland's team discovered a different and quite unintuitive
route. Their reaction system, shown in green, combines the
carbon-nitrogen chemistry that leads to the bases with the
carbon-oxygen chemistry that makes the sugars. They make a
half-sugar/half-base (11), add another half-sugar (12) and then
a half-base to make an intermediate (13) that easily becomes
ribo-cytidine phosphate.
Ultra-violet light converts ribocytidine to the uracil-containing
nucleotide. The Manchester team has not yet found how to
mkae the other two nucleotides of which RNA is composed, but
this should not be an insuperable problem.
Once the four nucleotides have been formed, they would fairly easily
zip together to make an RNA molecule. If Dr. Sutherland's work
is correct, it provides for the first time a plausible explanation of
how an information-carrying biological molecule like RNA could
have arisen on the primitive earth.
Reconstructing the master molecules … Nicholas Wade, Science, May 13, 2009
Music: Learning to listen
• Open your eyes.
• Listen with your whole intelligence.
• Composition in U L of B Almost
obsessional order.
• & Beethoven’s quartets: caveats
Order / fit obsessions
Unbearable Lightness
1 Lightness and Weight
17
2 Soul and Body
29
3 Words Misunderstood
11
4 Soul and Body
29
5 Lightness and Weight
23
6 The Grand March
29
7 Karenin’s Smile
7
145
(5 * 29)
Suppose that roses
always grew east a
likely spectre all
things ought to at
least behave! fail
as things do its a
kingly joke a kick
eternal east to be
charading to mimic
it as momento mori
tell everyone: art
yearns for ends by
undoing itself you
tuck pointed idiot
an evenness like a
hotly burning bush
•
-Leroy Searle
Beethoven 131 (14th Q)
•
•
•
1 Adagio
2 Allegro molto
3 Allegro moderato
4
(1)Andante,(2) piu mosso, (3)andante moderato,
(4)adagio,
(5)allegretto, (6) adagio, (7) allegretto
•
•
•
5 Presto
6 Adagio
7 Allegro
(7 sections: theme & variation, 6 of which are connected to earlier and
later movements, 1 self referential anchors main theme)
Reading to listen, not perform
• Bach, Two part invention # 1 C major
•
Three part sinfonia # 9 F minor
• Amateur intrusion: Do not be intimidated
by the big names. You CAN do it.