Transcript What is Biotechnology?

Acrylamide in Food Workshop
Contaminants and Natural
Toxicants Subcommittee
FDA Food Advisory Committee
College Park, MD
December 4, 2002
Background
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Ad hoc Acrylamide Working group
composed for food industry, trade
associations, academic and
government representatives
Began discussions shortly after
Swedish release in April
Workshop, concentrating on science,
was needed to openly discuss issues.
Acrylamide in Food Workshop
Title: Acrylamide in Food: Scientific
Issues, Uncertainties, and Research
Strategies
Dates: October 28-30, 2002
Location: O’Hare Ramada Plaza Hotel,
Chicago
Acrylamide in Food Workshop
Focus: Science – knowledge gaps and
research priorities
Target audience:
Food industry
Academia
Regulatory agencies (domestic and
international)
Goals/Objectives
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To develop conclusions on how
efforts of industry, government, and
academia can be coordinated to
effectively use available resources to
address the scientific issues raised by
the reports of acrylamide in foods,
including the final report of the
WHO/FAO Consultation.
Goals/Objectives
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Identify data gaps in scientific
knowledge – to reflect an international
perspective, to the extent possible
Identify research needs
Identify a select number of high-priority
research needs to be included in a
coordinated research agenda
Workshop Planning Committee to
identify list of short-term action items.
Participants
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170 present out of 171 acceptances
About 25 from outside the U.S. including
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Laurance Castle, CSL, UK
Bryan Hanley, Leatherhead Food RA, UK
Karl-Erik Hellenas, Swedish Natl. FA
Hans Lingnert, SIK, Sweden
Manfred Leutzow, FAO, Rome
Dennis Marroni, SNF-Floeger, France
Participants
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Donald Mottram, Univ. of Reading, UK
Mayumi Onishi-Kameyama, NFRI, Japan
Nadia Slimani, IARC/WHO, France
Margareta Tornqvist, Stockholm Univ.
Richard Stadler, Nestle Res. Ctr, Switzerland
Peter Varelis, CSIRO, Sydney
Carolyn Vickers, WHO, Geneva
Mitsuni Ito Yoshida, NFRI, Japan
Adam Becalski, Health Canada
Working Groups
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2.
3.
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Mechanisms of formation of
acrylamide in food
Analytical methods
Exposure and biomarkers
Toxicology and metabolic
consequences
Risk communication
Questions Addressed by
Each Working Group
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2.
3.
What are the primary areas
concerning the occurrence of
acryamide in food in which research
is needed?
Are methods currently available to
accomplish this research?
What is the time frame for getting
results for the research identified?
Questions Addressed by
Each Working Group
4.
5.
6.
What missing information is needed
to enable the proposed research to
be initiated or accomplished?
What questions will be answered by
each research area proposed?
Rank the research areas/projects
identified in order of priority for
accomplishment?
Questions Addressed by
Each Working Group
7. Where is your Working Group linked
to others, i.e., from what other
Working Groups do you need
assistance?
Workshop “Proceedings”
The proceedings of the workshop are posted
on the JIFSAN website
(http://www.jifsan.umd.edu) and include an
introduction, the workshop opening
overview, the “strawman” position paper –
summary of discussions - conclusions from
each Working Group, the priority research
needs identified, a listing of short-term
items, and a listing of participants.
Short-term Action Items –
Priority areas and projects:
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Analytical Methods
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Establish proficiency testing program and
materials.
Toxicology
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Develop data on the absorption, distribution,
metabolism, excretion of acrylamide
Develop and conduct studies on DNAprotein
glycidamide and acrylamide adducts to
determine metabolic consequences of
acrylamide.
Short-term Action Items –
Priority areas and projects:
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Methods of Formation
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Develop data for various foods on quantity of
free aspargine for various foods and data on
the quantity of glucose, fructose (and other
sugars) and other amino acids.
Develop data on
time/temperature/ph/moisture/surface areamass mapping and the kinetics of
asparagine/carbonyls reactions in various
matrices
Short-term Action Items –
Priority areas and projects:
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Methods of Formation
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Define the direct relation of asparagine
to acrylamide production in foods.
Develop data on the kinetics of
acrylamide
inhibition/destruction/scavenging under
various reaction/process conditions.
Short-term Action Items –
Priority areas and projects:
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Exposure
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Expand the database of acrylamide levels in
U.S. foods through collection of additional data
and establish mechanisms for information
sharing, such as the WHO/FAO Acrylamide in
Food Network operated by JIFSAN through its
Food Safety Risk Analysis Clearinghouse.
Develop and conduct appropriate animal and/or
human studies on the bioavailability of
acrylamide in foods.
Short-term Action Items –
Priority areas and projects:
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Risk Communication
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Conduct qualitative attitudinal research on
consumer awareness and knowledge of
acrylamide in food. Triggers for behavioral
change may be identified for acrylamide and
other potential health hazards.
Formally document the unique process used to
develop and accomplish the Acrylamide in
Food Workshop.
Short-term Action Items –
Priority areas and projects:
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Risk Communication
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Establish an information clearing house
and evidence review process with full
participation by a broad group of
stakeholders. The WHO/FAO Acrylamide
in Food Network provides the starting
foundation for this.
Acrylamide Infonet (WHO/FAO
Acrylamide in Food Network)
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Operated by JIFSAN
(http://www.acrylamide-food.org)
The objectives are:
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Phase 1 – to function as a global resource &
inventory of ongoing research, surveillance &
monitoring, industry investigations, etc.
Serve as a discussion forum and network for
active researchers/others in the field in order to
identify gaps and overlaps in research &
information, and make suggestions for how
these could be addressed
Acrylamide – EC Meeting
In Europe, the EC organized a stakeholder
meeting on October 15-16 for similar
purposes to the JIFSAN/NCFST workshop
in the U.S. The SCF and WHO/JECFA will
be leading the work on toxicology and
bioavailability, risk characterization and
communication; the CIAA will coordinate
the industry input and be their link with the
Commission and with international
organizations.
Acrylamide – EC Meeting
Cooperative Activity
Key Issue
USA
Analysis
NFPA
Europe
CIAA, Nat. author./
assocns (Nat. a/a)
Formation
IIT, NCFS CIAA, Nat. a/a
Exposure/
CIAA, Nat. a/a,
Bioavailability GMA
ILSI (Europe)
Toxicology
ILSI (NA) ILSI (Europe)
Risk Commun. IFIC
EUFIC