Transcript Document

Lecture 17
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Glucose energy production
Anabolic roles of TCA
Funky cycles…
Acetyl CoA
Amino acids, etc.
Oxaloacetate
Oxaloacetate
Malate
Malate
Citrate
Citrate
Fatty acids, etc.
Anaplerotic reactions
Compartmentalization
Glycolysis: Where is NADH produced?
Where is the ETC?
Moving NADH, 1: The Glycerol 3-PO4 shuttle
Moving NADH, 1: The Glycerol 3-PO4 shuttle
Moving NADH, 2: Malate-Asp shuttle
Moving NADH, 2: Malate-Asp shuttle
Moving others across mitochondria
How do we know about e- flow?
Can’t “label” electrons!
So, how to follow e- flow?
The ETC
Complex I
Complex II
Complex III
Complex IV
The ETC
The ETC
http://www.youtube.com/watch?v=RvqR4pExHX8
ETC
e- energy  Proton gradient
High energy e- from metabolism
Proton gradient  ATP?