Transcript 25_Clickers

Organic Chemistry, 6th edition
Paula Yurkanis Bruice
Chapter 25
The Organic Chemistry of the Coenzymes,
Compounds Derived from Vitamins
Brian L. Groh
Minnesota State University, Mankato
Mankato, MN
Bruice: Organic Chemistry, © 2011 Pearson Education, Inc.
25
Which of the following is not true of cofactors or
coenzymes?
A. They assist in catalyzing a variety of reactions.
B. They can be metal ions.
C. They may be organic molecules which are then
called coenzymes.
D. All vitamins function as coenzymes.
E. They may function as reducing or oxidizing
agents.
Bruice: Organic Chemistry, © 2011 Pearson Education, Inc.
25
Which of the following is not true of cofactors or
coenzymes?
A. They assist in catalyzing a variety of reactions.
B. They can be metal ions.
C. They may be organic molecules which are then
called coenzymes.
D. All vitamins function as coenzymes.
E. They may function as reducing or oxidizing
agents.
Except vitamin C all water soluble vitamins and
vitamin K are cofactors. The others are not.
Bruice: Organic Chemistry, © 2011 Pearson Education, Inc.
25.2
What enzyme is used in the following reaction?
CO 2SH
A.
B.
C.
D.
E.
SH
CO2-
FAD
S
S
Succinate dehydrogenase
Dihydrolipoyl dehydrogenase
Thiol dehydrogenase
Amino acid oxidase
FADH2 dehydrogenase
Bruice: Organic Chemistry, © 2011 Pearson Education, Inc.
+ FADH2
25.2
What enzyme is used in the following reaction?
CO 2SH
SH
A.
B.
C.
D.
E.
CO2-
FAD
S
S
+ FADH2
Succinate dehydrogenase
Dihydrolipoyl dehydrogenase
Thiol dehydrogenase
Amino acid oxidase
FADH2 dehydrogenase
There is no enzyme called thiol dehydrogenase.
Bruice: Organic Chemistry, © 2011 Pearson Education, Inc.
25.5
Pyridoxal phosphate (PLP) is required by enzymes
that catalyze transformations including:
A.
B.
C.
D.
E.
Decarboxylation
Transamination
Racemization
Alpha- and beta-eliminations and cleavages
All of the above
Bruice: Organic Chemistry, © 2011 Pearson Education, Inc.
25.5
Pyridoxal phosphate (PLP) is required by enzymes
that catalyze transformations including:
A.
B.
C.
D.
E.
Decarboxylation
Transamination
Racemization
Alpha- and beta-eliminations and cleavages
All of the above
Bruice: Organic Chemistry, © 2011 Pearson Education, Inc.
25.1, Which of the following coenzymes is used in
25.2, oxidations reactions?
25.7
A. THF
B. FADH2
C. NADH
D. NAD+
E. All of these
Bruice: Organic Chemistry, © 2011 Pearson Education, Inc.
25.1, Which of the following coenzymes is used in
25.2, oxidations reactions?
25.7
A. THF
NAD+ acts as a hydride
B. FADH2
acceptor. NADP+ is
C. NADH
another similar
D. NAD+
oxidizing agent.
E. All of these
Bruice: Organic Chemistry, © 2011 Pearson Education, Inc.
25.1, Which of the following coenzymes is not used in
25.2, reduction reactions?
25.8
A. Dihydrolipoate
B. FADH2
C. NADH
D. Vitamin KH2
E. None. All of these are reducing agents.
Bruice: Organic Chemistry, © 2011 Pearson Education, Inc.
25.1, Which of the following coenzymes is not used in
25.2, reduction reactions?
25.8
A. Dihydrolipoate
B. FADH2
C. NADH
D. Vitamin KH2
E. None. All of these are reducing agents.
All of these coenzymes are hydrogen donors.
Bruice: Organic Chemistry, © 2011 Pearson Education, Inc.
25.225.8
Which of the following enzymes is used in the transfer
of a single carbon?
A.
B.
C.
D.
E.
Vitamin KH2
Thiamine pyrophosphate (TPP)
Tetrahydrofolate (THF)
Pyridoxal phosphate (PLP)
Flavin mononucleotide (FMN)
Bruice: Organic Chemistry, © 2011 Pearson Education, Inc.
25.225.8
Which of the following enzymes is used in the transfer
of a single carbon?
A.
B.
C.
D.
E.
Vitamin KH2
Thiamine pyrophosphate (TPP)
Tetrahydrofolate (THF)
Pyridoxal phosphate (PLP)
Flavin mononucleotide (FMN)
THF is used in the transfer of groups containing
only one carbons such as –CH3, –CH2, and –HC=O.
Bruice: Organic Chemistry, © 2011 Pearson Education, Inc.