Transcript Training_dc110228_US-CPSC_Health

Overview of the
CPSC Directorate
for Health
Sciences *
Mary Ann Danello, Ph.D.
Associate Executive Director
* The views expressed in this presentation are those of the staff, have
not been reviewed or approved by, and may not represent the views
of the U.S. Consumer Product Safety Commission.
DETERMINE IF THERE IS A HUMAN HEATH EFFECT:
* TOXICOLOGICAL ASSESSMENT (EXPOSURE AND RISK ASSESSMENT)
* PHARMACOLOGICAL ASSESSMENT (RISK TO CHILDREN)
* PHYSIOLOGICAL/MEDICAL ASSESSMENT (SEVERITY AND LIKELIHOOD OF INJURY)
REGULATORY
DEVELOPMENT
NO RULE
DEVELOPMENT OF RULE
COMPLIANCE
ACTIVITY
NO COMPLIANCE ACTION
COMPLIANCE ACTION
–
Pharmacology
• Acute toxicity
• Poison prevention
–
Physiology
• Choking, suffocation, strangulation, and burn hazards
• Head injury
• Other traumatic injuries (eye, ear, intestinal, etc)
–
Toxicology and Risk Assessment
• Chronic and acute health effects-cancer, developmental and
reproductive toxicity, neurotoxicity, immunotoxicity/chemical
sensitization, inhalation
• Exposure and risk assessment
• International harmonization
• Alternatives to animal testing
Evaluate potential human health effects and
hazards of consumer products during reasonably
foreseeable uses
 Perform exposure and risk assessments for
product-related hazards
 Provide scientific advice and expertise for policy
development and implementation of CPSC
statutes
 Provide expertise to Office of Compliance to
support enforcement and compliance actions

Provide advice on international activities and
support the development of international
standards
 Support development of voluntary and
mandatory product safety performance
standards and test methods
 Develop testing procedures to identify productrelated hazards
 Respond to consumer inquiries on product
safety

Hazard Identification
and Reduction
- Projects
- Petitions
- Emerging Hazards
Hazard
Identification
and
Reduction
75%
Compliance
25%
Compliance
- CR-packaging and
CR-lighter
assessments
- Drug toxicity
assessments
- Household chemical
safety assessments
- Product safety
assessments
- Small parts choking
hazard assessments
–
Staff participate on interagency committees developing U.S.
positions for harmonization of:
– OECD test guidelines
– OECD guidance documents
– Globally Harmonized System for the classification and labeling
of chemicals
– Approaches to reducing use of animals in testing (through
ICCVAM )
–
Staff participation in international cooperative activities related to
nanotechnology (through the National Nanotechnology Initiative)
–
Staff assessment of GHS for possible implementation