Transcript Anti-tumour drugs

Anti-tumour drugs
Vinca
DEPARTMENT OF TECHNICAL EDUCATION
ANDHRA PRADESH
Name
Designation
Branch
Institute
Year
Subject
Subject Code
Topic
Sub-Topic
Duration
Teaching Aids
: R.D.L.P.Christian
: Lecturer in pharmacy
: Pharmacy
: GPW, Srikakulam(088)
: I year
: Pharmacognosy
: PH-103
: Anti-tumour drugs
: Vinca
: 50 min.
: PPT, Photographs
Recap
In the last class we learnt about
• The Anti-rheumatic drug COLCHICUM
• The important constituent of Colchicum is the Amino
alkaloid COLCHICINE
OBJECTIVES
On completion of this period you would be able to
learn about
The monograph of the anti-tumour drug
VINCA
Anti-tumour Drugs- Definition
• Agents used for the treatment of Cancer
• Cancer is abnormal cell growth (tumour)
• Clinical Conditions:
Hodgkin’s disease, Leukemia,
Cancer of lung, breast, stomach,
bladder, colon, prostate, testicles,
uterus, skin etc.,
Fig.43.1 Catharanthus roseus plant
Fig.43.2 Flower of periwinkle
VINCA
Syn: Periwinkle (English), Billaganneru (Tel),
Sadabahar (Hindi)
• Biological Source :
Dried whole plant of
Catharanthus roseus
• Family : Apocyanaceae
•
Geographical Source :
Indigenous to Madagaskar,
grows in India, Africa, East
Europe, Australia and India
Fig.43.3 Vinca plant
COLLECTION AND PREPARATION
Sowing of fresh seeds
2 months
6-7 cm height plants transplanted to open fields
6-9 months
Stems are cut, seeds, roots are collected, dried
Column chromatography (solvent extraction)
Alkaloids
MORPHOLOGICAL CHARACTERS
LEAF
• Size
•
•
•
•
: Length: 3-5 cm,
Width:1-2 cm
Shape : Ovate, oblong
Colour : Green
Odour : Characteristic
Taste : Bitter
Fig.43.4 Vinca plant
MORPHOLOGICAL CHARACTERS
FLOWER
Three varieties of plants:
1. Vinca alba :
White flowers
2. Vinca rosea :
Rose pink flower
3. Vinca oscillata
:
White flowers with
Purple centre
Fig.43.5 Vinca plant
CHEMICAL CONSTITUENTS
• Contains a large number of Indole alkaloids
• Out of them 20 are Dimeric Indole - dihydroindole
alkaloids
• Among which VINCRISTINE and VINBLASTINE are
most significant
CHEMICAL CONSTITUENTS
• Vincristine contains Indole alkaloid part
CATHARANTHINE and Dihydroindole alkaloid part
called VINDOLINE
• Other alkaloids AJMALICINE, LOCHNERINE,
SERPENTINE and TETRAHYDROALSTONINE
USES
• The alkaloids are having ONCOLYTIC activity
• Vincristine Sulphate and Vinblastine Sulphate are
Anti-neoplastic agents
• Vincristine Sulphate given I.V. in the treatment of
Leukemia in children
• Used in Hodgkin’s disease
• Vinca also has Hypotensive & Anti-diabetic action
SUMMARY
In this class we learnt about
• The monograph of the Anti-tumour drug VINCA
• It contains VINCRISTINE and VINBLASTINE
which are very effective Anti-neoplastic agents
QUIZ
Q 1) VINCA belongs to the family
a) Compositae
b) Graminae
c) Apocynaceae
d) None of the above
QUIZ
Q 2) CANCER IS
a) Decreased growth of cells
b) Unlimited growth of cells
c) Arrested growth of cells
d) None of the above
QUIZ
Q 3) The important constituents of VINCA are
a) Resins
b) Glycosides
c) Alkaloids
d) None of the above
FREQUENTLY ASKED QUESTIONS
1.
Give example for Anti-tumour drug.
Write the Botanical Source and Morphology
2.
Write the Chemical Constituents and Uses of Vinca
3. Write the Botanical Source, Chemical Constituents and
Uses of Vinca