Transcript Project I - Wake Forest Clinical and Translational Science Institute

Center for the Neurobiology of
Addiction Treatment
Overview
Wake Forest University Health Sciences
Established: 1991
Cost to US Economy of Addiction: $712 billion
2015 Monitoring the Future Study
Prevalence of Past Year Drug Use – 12th
Graders
Treatment Medications
Alcohol
60.2
Campral, Revia
Marijuana
35.1
None
Narcotics
6.1
Methadone, Suboxone
Cigarettes (past 30
days)
13.6
NRT, Chantix, Welbutrin
Amphetamines
8.1
None
MDMA (Ecstasy)
3.6
None
Cocaine
2.6
None
Ritalin
1.8
None
Wake Forest School of Medicine
Special Relevance to WFBMC
• Approximately 200 patients per day in WFBMC
with substance-related complications
• 30% of hospital admissions are alcohol/drug
related
• 45% of ED admissions are alcohol/drug related
DSM-V: The essential feature of a substance use disorder is a cluster of
cognitive, behavioral, and physiological symptoms indicating that the
individual continues using the substance despite significant substancerelated problems.
Suboxone outsells Aderall and Viagra
SPECIFIC AIMS
1. To provide a novel mechanism of interaction among NIDA investigators at
WFU to examine neurobiological mechanism of cocaine pharmacotherapies.
2.
To provide a formal structure of collaborative interactions between our
Center and our clinical partners at NIDA-funded clinical centers.
3.
To provide a focus for the training of students and postdoctoral fellows in
contemporary methods for investigating the neurobiological basis of drug
abuse.
4.
To serve as an informational source to both the lay and scientific community
on issues related to the neurobiology of drug abuse.
CNAT Structure
Project 1: Behavioral Evaluation of Novel Pharmacotherapies
Animal models, cognition, telemetry, medication development
Michael Nader, Paul Czoty, Jeff Martin, Mark Ferris, Holden Ko, Daniel
Yohannes
Project 2: Brain Functional Evaluation of Novel Pharmacotherapies
PET imaging, microdialysis, voltammetry, multi-unit neural recording
Linda Porrino, Sara Jones, Sam Deadwyler, Robert Hampson
Project 3: Molecular/Biochemical Evaluation of Novel Pharmacotherapies
Receptor pharmacology, neural signaling, gene therapy
Allyn Howlett, Steve Childers, Rong Chen
Pilot
Grant
Core
Tissue
Core
Clinical Centers:
Baylor Coll Med
U Pennsylvania
Pilot Core: Sara Jones, PI
The Specific Aims are:
1. To solicit and review pilot project proposals.
2. To provide mentorship to ensure further training and career
development of investigators receiving pilot funds, particularly
new and early stage investigators.
3. To provide support for highly innovative preliminary studies
from established investigators.
4. To encourage submission of R01 or other grant applications
based on results from pilot studies.
Rong Chen, Mark Ferris, Holden Ko, Daniel Yohannes
CNAT Outreach
1. Brain Awareness Week
2. Kernersville Cares For Kids
3. WSSU Summer Science Scholars Program
4. Treatment and Prevention Practitioners: Provide training to NC
Parent Network
5. Youth Education
6. Interactions with journalists
Center for the Neurobiology of Addiction
Treatment
Phys/Phar
m
PHS
Neurobiol/
Anat
Primate
Center
WFI
CNAT
Radiology
Sticht
Center
Psychiatr
y
Anesthesiology
CTSI
Pilot Funding Roundtable
Discussion Leader: Lynne Wagenknecht, DrPH
Pilot Funding Opportunities - Centers
PILOT FUNDING OPPORTUNITIES
PILOT DESCRIPTION
CCC - Push Pilots (one per CCC Program)
CCMR - Animal research pilots
CIIRRC - Pilot Awards
CPHG - Planned pilot awards annually
HVRC - Pilot Funding
MACHE - Health Disparities/Health Equity
MACHE - Travel Awards
Wake Forest Baptist Medical Center
AMOUNT
TARGETED DATE FOR SUBMISSION
$40,000/each
9/9/15; now under review
$5,000 each (3)
November 30, 2015
$6,000 each
August (2 planned 2016)
TBD
March (1 planned 2016)
$3,000-$4,000 each
rolling submissions throughout year
$25,000 (1)
FY16 (date TBD)
$1,500 each (5 awards)
3 months prior to travel date
11
Pilot Funding Opportunities - Institutes
PILOT FUNDING OPPORTUNITIES
PILOT DESCRIPTION
AMOUNT
TARGETED DATE FOR SUBMISSION
CTSI - Clinical Informatics Pilot
$40,000 (1)
11/11/15 (based on invite from LOI)
CTSI - Community Engagement Pilot
$40,000 (1)
11/11/15 (based on invite from LOI)
CTSI - Ignition Fund
up to $5,000
monthly Oct 2015-June 2016
CTSI - Implementation Science Pilot
$40,000 (1)
11/11/15 (based on invite from LOI)
CTSI - Open Pilot
$40,000 (4)
11/11/15 (based on invite from LOI)
CTSI - Open Pilots
$40,000 (4)
Spring 2016
CTSI - Targeted Pilots
$40,000 (4)
Spring 2016
WFI - Commercialization Pathway Awards. To
fund early product ideas
Approximately between
$5,000 and $40,000
Rolling submission of RFAs
WFI - Technology Development Program. To
finance milestone-based development of
innovative technologies to point of licensing
Up to $15 million over the
next 3-5 years
Submission details to be announced
shortly – see
Your.WakeForestInnovations.com
Wake Forest Baptist Medical Center
12
Discussion
Discussion Leader: Lynne Wagenknecht, DrPH
Wake Forest Baptist Medical Center