Transcript Folie 1 - uni-stuttgart.de

Teilprojekt 5
Multiscale Modelling of Drug
Transport and Action in
Vascular Tumours
Matthias Reuss
Activities during FORSYS Partner project (2008-2011)
Projektteil A
Tumour Reconstruction/
Diffusion
Projektteil B
Vascular tumour growth
and angiogenesis
Projektteil C
Tumour spheroids
Histological slices
(Pichler/Schwab)
Integrin / ECM interaction (extension of existing tumour growth model)
Experimental validation with tumour spheroids (Scheurich)
TissueVision3D
Influence on cell motility (haptotaxis) and
inclusion of anti-apoptotic effect (cFlip / Bcl-2)
3D Tissue
reconstruction
Diffusion of molecules
Comparison to experimental
data
Pichler (MRI)/
Pfizenmaier (FRAP)
Hybrid simulations
Cell distribution from imaging
Coarsing of concentration
fields, comparison to
experimental data (Pichler)
Integration of TRAIL apoptosis
pathway model
(Allgöwer)
Model validation
(Scheurich)
Link to other cellular automaton model P7 (Helmig)
P5 / P7
P7
P5
Teilprojekt 7
Helmig
Teilprojekt 5
Reuss