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Title Slide
Strategic Center for
Clinical Cancer Research
Clinical Cancer Research using
Emerging Advanced Technologies for Health
Breast Cancer Mortality in Women, 1951-2000
Strategic Center for
Clinical Cancer Research
Lancet: 365,1727,2005
The CREATE Health team
Strategic Center for
Clinical Cancer Research
Nano technology
Proteomics
Clinical Oncology
Tumour biology
Bioinformatics
Genomics
Proteomics
Organisation
Scientific Secretary
CREATE Health Board
Representatives from
Lund University and
Industry
Strategic Center for
Clinical Cancer Research
Director Carl Borrebaeck
Deputy Carsten Rose
Steering Committee
Financial Officer
Scientific Advisory Board
IPR Review board
Administration
Bioinformatics
C Peterson
DNA/RNA
arrays
Å Borg
RNA/protein
arrays
C Borrebaeck
Proteomics
P James
Nanotechnology
T Laurell
Clinical Oncology
C Rose
Tumor cell
biology
S Påhlman
J Häkkinen
J Vallon
C Rovira
S Ek
C Wingren
F Levander
G Marko-Varga
J Nilsson
C Graffman
M Ridderheim
H Axelson
C Larsson
Localisation of BMC and USil
Strategic Center for
Clinical Cancer Research
Localisation at the Biomedical Centre
Strategic Center for
Clinical Cancer Research
You are here!
Mission and Vision Statements
Strategic Center for
Clinical Cancer Research
• To create an integrative approach to solve complex
clinical problems, by developing novel techniques ”from bedside to bench and back again”
• To create a substantial social impact for the patient
through direct application of research for selection
of an optimal, individually-based, cancer treatment
Research and Development
Strategic Center for
Clinical Cancer Research
Clinical focus
To associate specific gene and/or protein signatures with:
• Treatment-induced drug resistance
• Treatment response & optimisation
• Tumour relapse & survival time
To identify novel targets for antibody-based therapy
CREATE Health Work flow
Strategic Center for
Clinical Cancer Research
Clinic
CREATE Health Centre
Sample handling
Sample
collection
Sample
storage &
tracking
Technology development & application
Sample
processning
Sample
analysis
Technology development
Investigators:
Carl Borrebaeck
Åke Borg
Peter James
Thomas Laurell
Carsten Peterson
Sven Påhlman
Carsten Rose
Clinic
Data
analysis &
mining
Clinical
transfer
Diagnostics/Treatment
Diagnostic
validation
Treatment
validation
Benefits for the patients
Strategic Center for
Clinical Cancer Research
Improved diagnosis
• Increased analytical sensitivity and capacity
Improved prediction of disease progression
• Proteome-wide biomarker identification from fine
needle/sure-cut biopsies
Increased survival
• Disease stratification and tailoring of therapy
• Tumour specific antibodies for therapy
Discovery Projects
Strategic Center for
Clinical Cancer Research
Genomics focus
• define gene defects that are hereditary
• define chromosomal defects arising in cancer
• develop pathway focused gene monitoring methods
• find novel microRNA markers of cancer
Proteomics focus
• discover protein markers of disease in cancer cells
• validate markers in serum for subsequent blood tests
• develop peptide monitoring for plasma analysis
Practical Application Projects
Strategic Center for
Clinical Cancer Research
Antibody microarrays
• antibody microarray based oncoproteomics
• nanostructured high performance chips for fluorescence/MS
• protein sampling in nanoscale for LCM single cell proteome
Proteomic data basis & tools
• BASE & Proteios integrated algorithms for breast & lymphomas
• Cell reconstruction & validation
Principle of Antibody Microarrays
Strategic Center for
Clinical Cancer Research
Practical Example:Pancreatic
Adenocarcinomas
Strategic Center for
Clinical Cancer Research
Analysis of serum
proteomes from 30
pancreatic
carcinoma patients and
15 healthy individuals
• red - upregulated
• black - no change
• green - down regulated
100% Sensitivity
100% Specificity
Healthy
Carcinoma
Technology Transfer and Commercialisation
Strategic Center for
Clinical Cancer Research
CREATE Health is actively engaged in developing its
discoveries to benefit society and has a special board for
IP issues.
The CREATE Health team has generated > three worldwide patents/year over the past five years, ranging from
basic research to applied biomedical inventions
As a result, six spin-off firms have been created, some
with > 100 employees.
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Strategic Center for
Clinical Cancer Research
www.createhealth.lth.se