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Nature Volume: 520, Pages: 389–393 Date published: (16 April 2015) DOI: doi:10.1038/520389a Published onli
ne 15 April 2015
Technology Feature
Cancer: A most exceptional response
Sometimes a drug causes a tumour to completely recede, but only in a tiny percenta
ge of people. Scientists want to decipher such outlier responses for the benefit of all
patients.
Vivien Marx
Nature Volume: 520, Pages: E11–E12 Date published: (16 April 2015) DOI: doi:10.1038/nature14265
MAGI3–AKT3 fusion in breast cancer amended
Juan-Miguel Mosquera,1, 2, * Sonal Varma,1, * Chantal Pauli,1, 2, 3,Theresa Y. MacDonald,1Jossie J. Yashinskie,1Zsuzs
anna Varga,3, Andrea Sboner,1, 2, 4, Holger Moch,3, Mark A. Rubin1, 2, § & Sandra J. Shin1, §
Banerji et al.1 described a novel MAGI3–AKT3 rearrangement in breast cancer, enriched in triplenegative tumours; the report was highly encouraging as targeted therapies could potentially ser
ve as a new and much needed option to treat this highly aggressive breast cancer
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Nature Volume: 520, Pages: 300–302 Date published: (16 April 2015) DOI: doi:10.1038/nature14382
News & views
Cancer: An extravascular route for tumour cells
Mary J. C. Hendrix
Molecular tracing of populations of breast-cancer cells in a primary tumour in mice r
eveals that two proteins, Serpine2 and Slpi, enable tumour cells to form vascular-like
networks, facilitating perfusion and metastasis.
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